Important factors in the nasal manifestation of allergy

Archives of Oto-rhino-laryngology
H Ohtsuka, M Okuda

Abstract

To elucidate whether or not histamine can be released by antigen from the nasal surface layer in sufficient quantities to produce nasal manifestation of allergy and which among three factors, i.e., the number of surface basophilic cells, the histamine release from these cells, or the mucosal histamine sensitivity, is the most responsible for the degree of nasal allergen provocation, we determined the allergen-induced histamine release from specimens of the mucus-epithelial layer of patients with nasal allergy and also counted the number of basophilic cells in these specimens after staining by Hansel's method. In addition, we evaluated the histamine sensitivity of the mucosa by the end-point test. The net histamine content released from the specimens of the nasal surface ranged from 25.5--310.7 microgram/cm3, which was found to be sufficient to produce nasal manifestation of allergy. Thye correlation coefficients were calculated as the relationships between the degree of provocation reaction and the level of histamine released from the nasal surface, the basophilic cell number, histamine releasability and histamine reactivity. these values were 0.645, 0.440, 0.481, and 0.155, respectively, and, when they were analyzed statistica...Continue Reading

References

Oct 31, 1978·Archives of Oto-rhino-laryngology·M OkudaH Otsuka

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Citations

May 1, 1993·The Journal of Laryngology and Otology·H OtsukaT Fujikura
Jun 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y AbeT Matsunaga
Nov 24, 1999·Allergy·M Okuda
Apr 6, 2006·Biological & Pharmaceutical Bulletin·Miho TakuboChiaki Kamei
Nov 6, 2007·Biological & Pharmaceutical Bulletin·Yosuke SunadaChiaki Kamei
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H OtsukaM Okuda
Feb 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y AbeT Matsunaga
Feb 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S KawaboriT Tosho
Jul 1, 1988·The Annals of Otology, Rhinology, and Laryngology·J WilsonA Maran
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·Ruby Pawankar
Feb 26, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Pawankar
Sep 1, 1988·The Journal of Allergy and Clinical Immunology·M Castells, L B Schwartz

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