Impregnation of healthy nail tissue with optical clearing agents for improved optical coherence tomography imaging.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Vinzent Kevin OrtnerPeter Alshede Philipsen

Abstract

The impact of optical tissue clearing on optical coherence tomography (OCT) for nail tissue imaging has not been investigated. This study seeks to compare the effects of an emollient and water on visualization of micromorphology and morphometric outcomes. Thirty-six healthy nail plates were processed with a fractional CO2 laser, imaged with OCT, and measured with calipers in duplicates. All samples were reassessed after 12-hour long sequential immersion in water and an emollient (Crodamol™ STS). OCT images were evaluated for thickness and scattering signal of the nail. Emollient-impregnation caused stronger scatter responses (P < .0001) and decreased nail thickness (MD 45 μm, P < .0001) measured on OCT. Caliper-derived measurements were not affected by Crodamol™ (MD 11 μm, P = .5538). Hydration increased nail thickness on OCT (MD 49 μm, P < .0001) but reduced thickness measurements taken with calipers (MD 41 μm, P < .0001). Emollient-impregnation improved visualization of onychocytes compared with dry (P = .0209) and hydrated samples (P < .0001), and reduced occurrence of refractive artifacts (P < .0001). The use of an emollient for OCT imaging can enhance nail tissue visualization without significant effects on caliper measure...Continue Reading

References

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Apr 17, 2001·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·J Welzel
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Feb 25, 2017·Skin Appendage Disorders·Adam S AldahanAntonella Tosti

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