Impression cytology study of conjunctival epithelial phenotypes on the healing ocular surface after pterygium excision

Cornea
S H TsengF K Chen

Abstract

To compare the process of conjunctival epithelial regeneration after three types of pterygium excision procedures. Thirty-eight patients (45 eyes) with primary pterygium were randomly assigned to a bare-sclera procedure (group 1, 15 eyes of 12 patients), bare-sclera with intraoperative mitomycin C (MMC 0.02% for 30 seconds; group 2, 15 eyes of 14 patients), or pterygium excision with conjunctival autografting (group 3, 15 eyes of 12 patients). Controls were healthy fellow eyes and seven eyes of age- and sex-matched subjects. Impression cytology was performed preoperatively, at 1 and 2 weeks, and at 1, 3, 6, and 12 months after surgery. The nucleus-to-cytoplasm (N/C) ratio of nongoblet epithelial cells and goblet cell density (GCD) in the pterygial area were calculated and compared over time across treatment groups. Pterygium excision wounds healed in a similar four-stage process in all groups, but at different rates and with different final results. The N/C ratio was highest at about 1 month postoperatively in groups 1 and 2 and at 2 weeks in group 3, before gradually returning to control levels. Preoperatively, the GCD in treated eyes was almost twice that in control eyes (p = 0.001) but fell to zero immediately postoperativel...Continue Reading

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Citations

Apr 27, 2004·Experimental Eye Research·Margarita CalongeJosé M Herreras
Mar 5, 2003·American Journal of Ophthalmology·Norihiko YokoiShigeru Kinoshita
Jul 23, 2008·Ophthalmic Plastic and Reconstructive Surgery·Jong Hyun KimSang In Khwarg
Feb 28, 2006·Current Eye Research·Shiro MizoueYuichi Ohashi
Aug 19, 2007·American Journal of Ophthalmology·Cinoo KimWon Ryang Wee
Apr 20, 2004·Progress in Retinal and Eye Research·Nick Di GirolamoDenis Wakefield
Jun 18, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Gemma JulioM Soledad Marqués-Calvo
Jan 31, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Sang Beom HanWon Ryang Wee
Mar 28, 2018·European Journal of Ophthalmology·Amanda García TiradoLuis Rivas Jara
Sep 2, 2003·European Journal of Ophthalmology·M MorenoJ Garcia-Campos

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