Imprint cytology of nasopharyngeal biopsies

Acta Cytologica
T Y ChaoT Y Tsao

Abstract

To use an instant cytologic diagnostic method to examine touch imprints of nasopharyngeal (NP) biopsies. This method aimed to ensure the adequacy of biopsied specimens for histologic examination. This paper describes the morphologic findings of NP lesions examined by this method. Imprints were made from NP biopsies from patients suspicious for nasopharyngeal carcinoma (NPC). These imprints were air dried, stained with Diff-Quik and examined immediately. The adequacy of the specimens was assessed, and the findings of the imprints were interpreted as positive-, negative- or suspicious for NPC. Repeat biopsies and cytologic studies were done as indicated. In selected cases, immunocytochemical staining was done to identify cells on the imprints. Histologic examination of the biopsied specimens served as the control. With this method we could interpret the imprints within five minutes of their receipt and determine if repeat biopsy was needed. In benign lesions, the imprints often contained many cells, most mature and reactive lymphocytes. These cells and the numerous lymphoglandular bodies (fragments of lymphoid cytoplasm) intermingled with the ciliated and squamous epithelial cells. In cases of NPC, the appearance was discrete, or...Continue Reading

Citations

Feb 14, 2006·Diagnostic Cytopathology·Mei-Hua TsouShyuang-Der Terng
Dec 16, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M R HusseinK A Hassanein
May 24, 2019·Acta Cytologica·Amit Kumar AdhyaRanjan Mohanty

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