Imprinted genes are up-regulated by growth arrest in embryonic fibroblasts

Journal of Biochemistry
T HayashidaH Sasaki

Abstract

It was previously reported that the imprinted insulin-like growth factor II and H19 genes are up-regulated in embryonic fibroblasts upon growth arrest. We have examined six other imprinted genes and found that all were up-regulated upon confluency and at least four of them by serum starvation. The significance of the results was confirmed by demonstrating that only one-third of randomly selected genes are up-regulated upon confluency. Our findings suggest that the cell cycle should be carefully controlled when imprinted genes are studied in cell cultures. Moreover, the unique property could have significance in the mechanistic or the evolutionary aspect of imprinting or both.

Citations

Sep 13, 2001·Molecular Reproduction and Development·K L JonesM Westhusin
Jun 4, 1998·Current Opinion in Genetics & Development·W Reik, J Walter
Feb 5, 2016·Proceedings. Biological Sciences·Manus M PattenRobert Feil
Dec 18, 2013·The Journal of Investigative Dermatology·Nan-Hyung KimAi-Young Lee
Feb 12, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Teodora RibarskaWolfgang A Schulz
Aug 26, 2003·The American Journal of Pathology·Bruno StuhlmüllerRaimund W Kinne
Jan 27, 2005·Cloning and Stem Cells·Karen L Jones, Kelly D Tarochione-Utt
Sep 27, 2002·Molecular Carcinogenesis·Suhail AyeshAbraham Hochberg
Jun 8, 2019·Epigenomics·Weilin ChenHonglin Zhu

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