Abstract
We studied 22 dogs to examine the effect of basic fibroblast growth factor (bFGF) alone, in comparison with omental or muscular wrapping on airway healing in a tracheal autotransplantation model. Basic fibroblast growth factor is one of the most potent promoters of angiogenesis and has an ability to enhance blood supply to the ischemic airway. Topical administration of a fibrin glue enriched with 5 microg/cm2 bFGF, determined as a proportion of surface area of the tracheal grafts, improved revascularization of orthotopic canine tracheal autografts in a previous study. All animals received orthotopic tracheal transplantation using 6-ring autografts that occupied a distal part of the thoracic trachea. Twenty-two animals were classified randomly into the following four groups: no treatment (Group G1, n = 4), muscular wrapping (Group G2, n = 4), omental wrapping (Group G3, n = 4), and topical administration of fibrin glue enriched with 5 microg/cm2 bFGF (Group G4, n = 10). Autografts were harvested 60 days after transplantation and assessed by the percent patency and histology. Devascularized tracheal autografts could not maintain their structural integrity without other treatments (Group G1). In contrast, more than half of all aut...Continue Reading
References
Jan 1, 1975·Scandinavian Journal of Thoracic and Cardiovascular Surgery·L Virkkula, S Eerola
Aug 1, 1991·The Annals of Thoracic Surgery·V M OlechG A Patterson
Mar 1, 1991·Journal of UOEH·R Nakanishi, T Shirakusa
Apr 1, 1990·The Annals of Thoracic Surgery·M W TurrentineJ W Brown
Jun 1, 1990·The Journal of Thoracic and Cardiovascular Surgery·P C PairoleroP P Kay
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
May 1, 1987·Endocrine Reviews·D GospodarowiczG Neufeld
May 1, 1988·The Journal of Investigative Dermatology·E J O'KeefeR E Payne
May 1, 1988·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·B L EppleyJ Feder
Sep 9, 1988·Science·J A ThompsonT Maciag
Oct 31, 1988·Biochemical and Biophysical Research Communications·P CuevasA Baird
Jan 1, 1986·Endocrinology·D GospodarowiczP Bohlen
May 10, 1974·Nature·D Gospodarowicz
Apr 1, 1994·The Annals of Thoracic Surgery·R NakanishiT Takachi
Sep 1, 1995·The Annals of Thoracic Surgery·R Nakanishi, K Yasumoto
May 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·R NakanishiT Shirakusa
Oct 1, 1993·The Annals of Thoracic Surgery·R C DalyM H Yacoub
Feb 1, 1994·The Annals of Thoracic Surgery·J M AlbesH G Borst
Feb 1, 1993·The Annals of Thoracic Surgery·K InuiA Haverich
Jan 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·R NakanishiK Yasumoto
Jan 13, 1906·British Medical Journal·R Morison
Citations
Mar 2, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ryoichi Nakanishi, Kosei Yasumoto
Jan 13, 2001·The Annals of Thoracic Surgery·R NakanishiK Yasumoto
Sep 15, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R NakanishiK Yasumoto
Aug 7, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ryoichi NakanishiKosei Yasumoto
Mar 19, 2009·Tissue Engineering. Part a·Andreas ArkudasUlrich Kneser
Jun 24, 2004·Annals of Surgery·Derek A DubayMichael G Franz
Feb 21, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Martin C RobsonMichael G Franz
Sep 1, 2007·Molecular Medicine·Andreas ArkudasUlrich Kneser
Jul 31, 2014·The Journal of Laryngology and Otology·F Villegas-AlvarezJ F González-Zamora
Feb 28, 2008·World Journal of Surgery·Matthias Behrend, Eva Kluge
Jan 24, 2009·Cryobiology·Hong XuDan Lu
Sep 16, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Seiichi FukuyamaYosihiko Maehara
Sep 12, 2007·Clinical Transplantation·Ryoichi Nakanishi
Jan 17, 2014·The Laryngoscope·Lukas H KusEvan J Propst
Nov 4, 2004·The Journal of Surgical Research·Ryuichi SuemitsuYoshihiko Maehara
Feb 15, 2001·The Journal of Thoracic and Cardiovascular Surgery·M HashimotoK Yasumoto
May 11, 2012·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Alejandro M BertolottiRoberto R Favaloro
May 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·R NakanishiK Yasumoto
Nov 23, 2016·European Journal of Clinical Investigation·Elena Arellano-OrdenMiguel Ángel de Gregorio
Nov 13, 2004·The Annals of Otology, Rhinology, and Laryngology·Satish GovindarajEric M Genden
Oct 6, 2000·Ophthalmic Plastic and Reconstructive Surgery·C N SoparkarD Appling
Jun 9, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Matthias BehrendWolfgang Schüttler
Jan 5, 2010·Organogenesis·Ryoichi Nakanishi
Mar 17, 2004·Archives of Facial Plastic Surgery·Matthew R KaufmanWilliam Lawson
Dec 18, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Jin SunWende Xiao