Improved Alertness Is Associated with Early Increase in Serum Brain-Derived Neurotrophic Factor and Antidepressant Treatment Outcome in Major Depression

Neuropsychobiology
Thorsten MikoteitJohannes Beck

Abstract

In major depression cognitive impairment is common and may persist despite improvement in psychopathology. So far it is unclear how closely related improvement in cognitive functioning is to the clinical course of depression. Further, it is unclear whether recovery from cognitive impairment is linked to changes in serum brain-derived neurotrophic factor (sBDNF). The objectives of this study were (1) to explore the predictive value of cognitive impairment for therapeutic outcome, and (2) to assess the association between cognitive performance and sBDNF levels over a 6-week course of antidepressant treatment. Twenty-five adult patients suffering from major depression underwent standardized treatment with duloxetine. Both severity of depression as assessed by the Hamilton Depression Rating Scale and sBDNF levels were measured at baseline, and after 1, 2 and 6 weeks of treatment. Cognitive performance, i.e. alertness, working memory, and divided attention, was assessed at baseline, after 1 week, and at the end of treatment after 6 weeks. Higher performance in alertness and divided attention at baseline correlated with less severe depression at week 6. During the first week of treatment, a greater increase in sBDNF was associated wi...Continue Reading

Citations

Feb 13, 2016·Journal of Psychiatric Research·Thiago Fernando Vasconcelos FreireMarcelo Pio de Almeida Fleck
Sep 22, 2018·The International Journal of Neuroscience·Amal Chandra Mondal, Mahino Fatima
Sep 28, 2017·International Journal of Methods in Psychiatric Research·Andrew T GlosterRoselind Lieb
Nov 9, 2019·Translational Psychiatry·Arielle S KellerLeanne M Williams
Sep 14, 2018·Frontiers in Psychiatry·Samantha J GrovesRichard J Porter
Feb 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaoxu WangGuangzhong Zhang
Mar 2, 2021·Frontiers in Behavioral Neuroscience·Beatrice ArosioIvan Aprahamian

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