Improved arteriole-to-venule ratio of retinal vessels resulting from bariatric surgery

Obesity
Alexander LammertHans-Peter Hammes

Abstract

Obesity causes increased morbidity and mortality from metabolic and cardiovascular disease (CVD). We investigated the effect of bariatric surgery on endothelial dysfunction (ED) in retinal vessels as a marker of metabolic and cardiovascular risk in patients with obesity WHO III.Thirty consecutive patients (19/11, w/m) were evaluated by anthropometry, lipid profile, and oral glucose tolerance test before and after bariatric surgery (Mannheim Obesity Study (MOS); NCT 00770276). Risk stratification was performed by the presence of metabolic syndrome (MetS) according to ATP-III (adult treatment panel-III). Subclinical atherosclerosis was assessed by measurement of intima-media thickness (IMT). Flicker light response of retinal vessels was used as measures of ED. We measured their arteriole-to-venule ratio (AVR) for evaluation of vascular pathology. After a median of 9 months following bariatric surgery, mean weight loss was 39.4 kg (37.3%). Remission of impaired glucose metabolism was achieved in 53.3% of affected patients. Dyslipidemia improved significantly (triglycerides -61.3 mg/dl, P < 0.0001, total cholesterol -28.2 mg/dl, P = 0.002, and low-density lipoprotein cholesterol were reduced -24.5 mg/dl, P = 0.008). This resulted i...Continue Reading

Associated Clinical Trials

Oct 9, 2008·Alexander Lammert

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Citations

Aug 10, 2013·Current Opinion in Cardiology·Swathi Appachi, Sangeeta R Kashyap
May 8, 2013·Microvascular Research·Christine BachmayerHans-Peter Hammes
Sep 27, 2012·Microvascular Research·Alexander LammertHans-Peter Hammes
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