Improved beta-amyloid PET reproducibility using two-phase acquisition and grey matter delineation

European Journal of Nuclear Medicine and Molecular Imaging
Otakar BelohlavekKaterina Simonova

Abstract

We investigated whether the reproducibility of standard visual reporting (STD method) in flutemetamol (FMM) PET can be improved using a newly introduced method that uses grey matter edges derived from the perfusion phase (GM-EDGE method). Two-phase FMM PET was performed in 121 patients with mild cognitive impairment. Five nuclear medicine physicians blindly and independently evaluated all late-phase scans, initially employing the STD method and later the GM-EDGE method. A five-point scale was used to express the degree of amyloid positivity, and a binary classification (positive/negative) was used in combination with subjective confidence (five-point scale). Multirater Fleiss' kappa, intraclass correlation coefficient (ICC) and inter-rater reliability (Cohen's kappa) were determined for the STD and GM-EDGE methods. The weighted Cohen's kappa values for the five-point measure of amyloid positivity ranged from 0.63 to 0.73 (median 0.70) for the STD method and from 0.76 to 0.89 (median 0.80) for the GM-EDGE method (ICC 0.84, 95% CI 0.79-0.88, for the STD method; 0.91, 95% CI 0.89-0.94, for the GM-EDGE method). The nonweighted Cohen's kappa value for the binary classification ranged from 0.73 to 0.93 (median 0.82) for the STD metho...Continue Reading

References

Jan 1, 2008·The Open Neuroimaging Journal·Gunnar BlomquistBengt Långström
Jan 25, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Ing-Tsung HsiaoKun-Ju Lin
Jun 7, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Roger LundqvistLennart Thurfjell
Jan 16, 2014·PloS One·Luping ZhouUNKNOWN AIBL Research Group
Aug 26, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lennart ThurfjellPaul Sherwin
Dec 3, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·William E KlunkMark A Mintun
Dec 9, 2014·NeuroImage·Yi SuUNKNOWN Dominantly Inherited Alzheimer Network
Sep 5, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Abhinay D JoshiMichael D Devous
Apr 24, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Garibotto ValentinaPagani Marco
Feb 6, 2018·World Journal of Nuclear Medicine·Karin KnešaurekUNKNOWN for Alzheimer's Disease Neouroimaging Initiative*
Jan 1, 2017·Nuclear Medicine Review. Central & Eastern Europe·Otakar Belohlavek, Monika Jaruskova

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Citations

Dec 15, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Ida SonniUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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Software Mentioned

MM Reading
MedCalc
MM
MIMneuro
Siemens syngo
via

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