Improved bioavailability of oxcarbazepine, a BCS class II drug by centrifugal melt spinning: In-vitro and in-vivo implications.

International Journal of Pharmaceutics
Sidra NasirMuhammad Sohail Arshad

Abstract

Poor bioavailability is a major obstacle in the development of an effective dosage form of the poorly soluble drugs. The present study aimed to improve the dissolution rate of a poorly soluble drug oxcarbazepine (OXC) exploiting the approach of surface area enhancement by fabricating drug loaded microfibers via centrifugal melt spinning (CMS) technique. For the generation of OXC loaded fibers, a well-known cotton candy process was used and the prepared fibers were characterized using SEM, DSC, XPRD and FTIR. Drug loaded fibers were also pressed into tablets which were also subjected to various in-vitro and in-vivo characterizations. The results have shown the formations of stable, amorphous, micro sized fibers, with average diameter of 6.0 ± 2 μm, loading efficiency > 80% and overall yield > 85%. In-vitro dissolution of OXC from fibers was > 90% within two minutes, which is ~ 5 times faster than that of pure drug. Pharmacokinetic data showed an improvement of ~ 25% and 35% in Cmax and AUC, respectively with two hours earlier Tmax. In-vivo studies in human oral cavity showed quick disintegration (45 ± 5 s) with > 90% OXC dissolved. The study concludes that the OXC incorporated in microfibers showed rapid in-vitro and in-vivo (or...Continue Reading

References

Oct 26, 1999·Epilepsia·E S Tecoma
Mar 17, 2004·International Journal of Pharmaceutics·S Sethia, E Squillante
May 26, 2007·The Journal of Pharmacy and Pharmacology·Dionysios DouroumisAlfred Fahr
Jun 26, 2007·Colloids and Surfaces. B, Biointerfaces·D Douroumis, A Fahr
Jul 16, 2009·Journal of Pharmaceutical Sciences·Katie M Lutker, Adam J Matzger
Jun 23, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Farhan AlhusbanAfzal R Mohammed
Oct 25, 2014·Drug Development and Industrial Pharmacy·Shashank JainSenshang Lin
Dec 3, 2014·International Journal of Pharmaceutics·U Eranka IllangakoonGareth R Williams
Mar 13, 2015·Journal of Pharmaceutical Sciences·Attila BaloghGyörgy Marosi
Apr 23, 2015·International Journal of Pharmaceutics·Wipada SamprasitPraneet Opanasopit
Mar 26, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Stefania MaranoDuncan Q M Craig
Nov 6, 2017·International Journal of Pharmaceutics·Michael A RepkaAjinkya M Bhagurkar
Nov 7, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gustavo Freire PetrovickJörg Breitkreutz
Jan 18, 2018·International Journal of Biological Macromolecules·Shazia Akram GhummanMateen Abbas
May 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Phennapha SaokhamThorsteinn Loftsson
Jul 24, 2018·Current Drug Delivery·Erick José Torres-MartinezLuis Jesús Villarreal Gómez
Dec 28, 2018·Pharmaceutics·Laura Modica de MohacBahijja Tolulope Raimi-Abraham
Feb 16, 2019·International Journal of Pharmaceutics·Yan YangJie Shen
May 18, 2020·Polymers·Paola Franco, Iolanda De Marco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Expert Review of Clinical Pharmacology
Bernhard J Steinhoff
Fortschritte der Neurologie-Psychiatrie
M FreidelH Vogel
Neurología : publicación oficial de la Sociedad Española de Neurología
S Arroyo
© 2021 Meta ULC. All rights reserved