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Improved Cas9 activity by specific modifications of the tracrRNA

Scientific Reports

Nov 6, 2019

Tristan A ScottKevin V Morris

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Abstract

CRISPR/Cas is a transformative gene editing tool, that offers a simple and effective way to target a catalytic Cas9, the most widely used is derived from Streptococcus pyogenes (SpCas9), with a complementary small guide RNA (sgRNA) to inactivate endogenous genes resulting from insertion...read more

Mentioned in this Paper

Gene Deletion
Genes
Genome
HIV Infections
Plasmids
RNA
Small Nuclear RNA
Streptococcus pyogenes
CD4 Positive T Lymphocytes
RNA, Guide
6
11
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Improved Cas9 activity by specific modifications of the tracrRNA

Scientific Reports

Nov 6, 2019

Tristan A ScottKevin V Morris

PMID: 31695072

DOI: 10.1038/s41598-019-52616-5

Abstract

CRISPR/Cas is a transformative gene editing tool, that offers a simple and effective way to target a catalytic Cas9, the most widely used is derived from Streptococcus pyogenes (SpCas9), with a complementary small guide RNA (sgRNA) to inactivate endogenous genes resulting from insertion...read more

Mentioned in this Paper

Gene Deletion
Genes
Genome
HIV Infections
Plasmids
6
11

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