Abstract
White blood cells (leukocytes) are a very important component of the blood that forms the immune system, which is responsible for fighting foreign elements. The five types of white blood cells include neutrophils, eosinophils, lymphocytes, monocytes, and basophils, where each type constitutes a different proportion and performs specific functions. Being able to classify and, therefore, count these different constituents is critical for assessing the health of patients and infection risks. Generally, laboratory experiments are used for determining the type of a white blood cell. The staining process and manual evaluation of acquired images under the microscope are tedious and subject to human errors. Moreover, a major challenge is the unavailability of training data that cover the morphological variations of white blood cells so that trained classifiers can generalize well. As such, this paper investigates image transformation operations and generative adversarial networks (GAN) for data augmentation and state-of-the-art deep neural networks (i.e., VGG-16, ResNet, and DenseNet) for the classification of white blood cells into the five types. Furthermore, we explore initializing the DNNs' weights randomly or using weights pretrai...Continue Reading
References
Apr 25, 2012·Journal of Pathology Informatics·Nisha RameshTolga Tasdizen
Jun 15, 2013·Journal of Pathology Informatics·Atin MathurManohar Kuse
Feb 25, 2015·Artificial Cells, Nanomedicine, and Biotechnology·S Ravikumar
Nov 20, 2016·Medicine·Pingping ZhouArun Upadhyaya
Feb 23, 2017·NeuroImage·Christian WachingerTassilo Klein
Apr 27, 2017·NeuroImage·Hao ChenPheng-Ann Heng
Oct 5, 2017·Computers in Biology and Medicine·U Rajendra AcharyaHojjat Adeli
Nov 22, 2017·Medical Physics·Aly A MohamedShandong Wu
Dec 15, 2017·IUBMB Life·Katherine E Badior, Joseph R Casey
Mar 27, 2018·Journal of Medical Systems·Shui-Hua WangHong Cheng
Apr 24, 2018·Computational and Mathematical Methods in Medicine·Sarmad Shafique, Samabia Tehsin
Jul 4, 2018·IEEE Transactions on Medical Imaging·Guotai WangTom Vercauteren
Jul 12, 2018·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Dongdong SunAo Li
Aug 17, 2018·BioMed Research International·William KingJennifer Woodell-May
Feb 5, 2019·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Ulysse Cote-AllardBenoit Gosselin
Mar 9, 2019·Journal of Biomedical Optics·Shike LiuJianguo Tian
Sep 19, 2019·Healthcare Technology Letters·Mohammad Mahmudul Alam, Mohammad Tariqul Islam