PMID: 9533145Apr 9, 1998Paper

Improved continuous light diffusion imaging in single- and multi-target tissue-like phantoms

Physics in Medicine and Biology
H JiangM S Patterson

Abstract

The image reconstruction enhancement schemes of total variation minimization, dual meshing and iterative spatial filtering have been applied to laboratory data collected from continuous light illumination of tissue-like phantoms. Experiments include both single- and multi-target cases where variations in object size (4 mm to 20 mm), position (centred to near boundary) and contrast with the background (2:1 to 8:1) have been explored. The results show that dramatic improvements in image quality have been obtained in terms of geometric and spatial resolution measures relative to those previously reported for continuous light, but quantitative information on the actual optical properties of embedded heterogeneities is still lacking. Specifically, the geometric characteristics of object size, position and shape are generally accurate to 10-20% and the spatial resolution metrics of background-to-object size and neighbouring-edge separation are approximately 10:1. Direct comparisons are also made with images obtained with intensity-modulated light under identical experimental conditions. Images from intensity-modulated light are found to be superior to continuous light in several important ways, most notably in terms of the ability to...Continue Reading

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Citations

Oct 19, 2005·IEEE Transactions on Medical Imaging·Antoine SoubretVasilis Ntziachristos
Aug 12, 2000·Journal of Biomedical Optics·M J HolbokeA G Yodh
May 30, 2003·Medical Physics·Xuejun GuHuabei Jiang
Oct 1, 2005·Medical Physics·Hongzhi ZhaoHuabei Jiang
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·V NtziachristosB Chance
Mar 10, 2010·Journal of Biomedical Optics·Krishna AgarwalXudong Chen
Oct 9, 2002·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Seungseok OhKevin J Webb
Jul 1, 2010·Reports on Progress in Physics·T DurduranA G Yodh
Aug 13, 2011·Biomedical Optics Express·Xiaoqi LiHuabei Jiang

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