PMID: 9447877Feb 3, 1998Paper

Improved contractility and coronary flow in isolated hearts after 1-day hypothermic preservation with isoflurane is not dependent on K(ATP) channel activation

Anesthesiology
D F StoweZ J Bosnjak

Abstract

Isoflurane protects against reperfusion injury in isolated hearts when given before, during, and initially after hypoxia or ischemia and aids in preconditioning hearts if given before ischemia. The aims of the current study were to determine if isoflurane is cardioprotective during 1-day, severe hypothermic perfusion and if a mechanism of protection is K(ATP) channel activation. Guinea pig hearts (n = 60) were isolated, perfused with Kreb's solution initially at 37 degrees C, and assigned to either a nontreated warm, time control group or one of five cold-treated groups: drug-free cold control, 1.3% isoflurane, 1.3% isoflurane plus glibenclamide (4 microM), 2.6% isoflurane, or 2.6% isoflurane plus glibenclamide. Isoflurane and glibenclamide were given 20 min before hypothermia, during low-flow hypothermia (3.8 degrees C) for 22 h, and for 30 min after rewarming to 37 degrees C. Heart rate, left ventricular pressure, %O2 extraction, and coronary flow were measured continuously, and responses to epinephrine, adenosine, 5-hydroxytryptamine, and nitroprusside were examined before and after hypothermia. Each group had similar initial left ventricular pressures, coronary flows, and responses to adenosine, 5-hydroxytryptamine, and nit...Continue Reading

References

Jan 1, 1989·The American Journal of Physiology·D M Bers
Jun 1, 1989·Anesthesiology·M KatsuokaS T Ohnishi
Jan 1, 1988·Scandinavian Journal of Thoracic and Cardiovascular Surgery·S LindalL Jørgensen
Jul 1, 1993·Journal of Molecular and Cellular Cardiology·D J HearseJ B Gavin
Oct 1, 1993·Chemistry and Physics of Lipids·K JørgensenM J Zuckermann

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Citations

Sep 25, 2003·British Journal of Anaesthesia·M ZauggM C Schaub
Jan 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Samhita S RhodesDavid F Stowe

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