PMID: 8468382Feb 26, 1993Paper

Improved detection limits for screening of diuretics by coupled liquid chromatography and ultraviolet-visible spectrophotometry

Journal of Chromatography
P Campíns-FalcóA Sevillano-Cabeza

Abstract

Experimental conditions have been studied in order to improve the sensitivity for the analysis of diuretics and probenecid in urine samples by high-performance liquid chromatography with ultraviolet detection. Sample clean-up and chromatographic parameters have been optimized to obtain a suitable sensitivity for the detection or quantification of each diuretic using an HP-Hypersil ODS-C18 column (5 microns, 250 mm x 4 mm I.D.), taking into account the pharmacological properties of each compound. The reliability of this method was tested by analysing urine samples after a minimum single-dose administration of chlorthalidone and probenecid.

Citations

May 23, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·R Herráez-Hernández, P Campíns-Falcó
Dec 6, 1996·Journal of Chromatography. B, Biomedical Applications·R Ventura, J Segura
Oct 29, 2013·Journal of Analytical Methods in Chemistry·Ibrahima Youm, Bi-Botti Celestin Youan
Aug 15, 2008·Journal of Pharmaceutical and Biomedical Analysis·M Espinosa BoschC Bosch Ojeda
Jul 18, 2009·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Fernanda PolloLeonardo Pezza

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