Improved detection limits of toxic biochemical species based on impedance measurements in electrochemical biosensors

Biosensors & Bioelectronics
B B NarakathuB E Bejcek

Abstract

An impedance based electrochemical biosensor was designed and fabricated for the detection of various chemical and biological species, with glass as substrate material and gold interdigitated electrodes. A flow cell with inlet and outlet ports for the microfluidic chamber was designed and fabricated using acrylic material with a reservoir volume of 78 μl. The feasibility of the fabricated sensor for detecting very low concentration of chemical and biological species was demonstrated. Electrochemical impedance spectroscopy (EIS) was employed as the detection technique. The impedance based response of the two-terminal device revealed a very high sensitivity with low concentrations of mouse monoclonal IgG, sarcosine, cadmium sulphide (CdS) and potassium chloride (KCl) at pico mole levels.

Citations

May 9, 2012·ACS Nano·R H FarahiT Thundat
Apr 4, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Linda M BrennanWilliam H van der Schalie
Aug 1, 2014·Biotechnology Progress·Sibel Emir Diltemiz, Okan Uslu
Oct 27, 2011·Journal of Diabetes Science and Technology·Brian R YoungMassood Z Atashbar
Jul 10, 2019·Physical Chemistry Chemical Physics : PCCP·F Rafael CastielloMaryam Tabrizian
Jun 23, 2015·Macromolecular Rapid Communications·Jaroslav LazarUwe Schnakenberg
Dec 3, 2020·Sensors·Angela Maria StortiniLigia Maria Moretto

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