Improved Detection of Cortical Gray Matter Involvement in Multiple Sclerosis with Quantitative Susceptibility Mapping

Academic Radiology
Shingo KakedaYukunori Korogi

Abstract

Quantitative susceptibility mapping (QSM) is a novel technique which allows determining the bulk magnetic susceptibility distribution of tissue in vivo from gradient echo magnetic resonance (MR) phase images. Our purpose was to evaluate if there is additional diagnostic value of QSM images in detecting the cortical gray matter involvement in multiple sclerosis (MS) patients. Our institutional review board approved this study. Conventional MR imaging, including T2-weighted imaging and two- or three-dimensional fluid-attenuated inversion recovery images, and QSM imaging examinations were performed in 27 patients (19 male and eight female) with MS. Two radiologists (radiologists 1 and 2) assessed the MS lesions in the following 3 anatomic regions: intracortical, mixed white matter-gray matter (WM-GM), and juxtacortical regions. The numbers of lesions per region category were compared between conventional MR images with and without QSM images. For radiologists 1 and 2, QSM images identified 6 (50.0%) and 7 (50.0%) additional lesions that were not seen in the conventional MR images, respectively. In a lesion-by-lesion analysis, the substantial fraction (20 [25.3%] of 79 at radiologist 1, 22 [29.7%] of 74 at radiologist 2) of juxtaco...Continue Reading

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Citations

Jan 20, 2016·International Journal of Molecular Sciences·Carsten StüberYi Wang
Apr 15, 2017·AJNR. American Journal of Neuroradiology·M CastellaroM Calabrese
Jan 24, 2018·Cold Spring Harbor Perspectives in Medicine·Christopher C Hemond, Rohit Bakshi
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Apr 9, 2016·Current Opinion in Neurology·Marloes HagensFrederik Barkhof
Mar 16, 2017·Journal of Magnetic Resonance Imaging : JMRI·Yi WangMartin R Prince
Mar 31, 2018·AJNR. American Journal of Neuroradiology·M MiyataY Korogi
Apr 8, 2019·Magnetic Resonance Imaging·Shun ZhangYi Wang

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