Improved detection of pulmonary nodules on energy-subtracted chest radiographs with a commercial computer-aided diagnosis software: comparison with human observers.

European Radiology
Zsolt Szucs-FarkasPeter Vock

Abstract

To retrospectively analyze the performance of a commercial computer-aided diagnosis (CAD) software in the detection of pulmonary nodules in original and energy-subtracted (ES) chest radiographs. Original and ES chest radiographs of 58 patients with 105 pulmonary nodules measuring 5-30 mm and images of 25 control subjects with no nodules were randomized. Five blinded readers evaluated firstly the original postero-anterior images alone and then together with the subtracted radiographs. In a second phase, original and ES images were analyzed by a commercial CAD program. CT was used as reference standard. CAD results were compared to the readers' findings. True-positive (TP) and false-positive (FP) findings with CAD on subtracted and non-subtracted images were compared. Depending on the reader's experience, CAD detected between 11 and 21 nodules missed by readers. Human observers found three to 16 lesions missed by the CAD software. CAD used with ES images produced significantly fewer FPs than with non-subtracted images: 1.75 and 2.14 FPs per image, respectively (p = 0.029). The difference for the TP nodules was not significant (40 nodules on ES images and 34 lesions in non-subtracted radiographs, p = 0.142). CAD can improve lesion...Continue Reading

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Citations

Sep 16, 2011·Academic Radiology·Nancy A Obuchowski
Oct 4, 2011·Academic Radiology·Diederick W De BooCornelia M Schaefer-Prokop
Aug 19, 2015·American Journal of Respiratory and Critical Care Medicine·Christopher G SlatoreUNKNOWN ATS Ad Hoc Committee on Setting a Research Framework for Pulmonary Nodule Evaluation
Oct 12, 2013·European Journal of Radiology·Steven SchalekampCornelia M Schaefer-Prokop
Mar 21, 2015·AJR. American Journal of Roentgenology·Lukas EbnerAndreas Christe
Nov 24, 2016·Acta Radiologica·Verena C ObmannEnno Stranzinger
Feb 4, 2021·European Journal of Radiology Open·Amit GuptaKai R Laukamp

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