Improved detection sensitivity of γ-aminobutyric acid based on graphene oxide interface on an optical microfiber

Physical Chemistry Chemical Physics : PCCP
Jun ZhouBai-Ou Guan

Abstract

Interfacing bio-recognition elements to optical materials is a longstanding challenge to manufacture sensitive biosensors and inexpensive diagnostic devices. In this work, a graphene oxide (GO) interface has been constructed between silica microfiber and bio-recognition elements to develop an improved γ-aminobutyric acid (GABA) sensing approach. The GO interface, which was located at the site with the strongest evanescent field on the microfiber surface, improved the detection sensitivity by providing a larger platform for more bio-recognition element immobilization, and amplifying surface refractive index change caused by combination between bio-recognition elements and target molecules. Owing to the interface improvement, the microfiber has a three times improved sensitivity of 1.03 nm/log M for GABA detection, and hence a lowest limit of detection of 2.91 × 10-18 M, which is 7 orders of magnitude higher than that without the GO interface. Moreover, the micrometer-sized footprint and non-radioactive nature enable easy implantation in human brains for in vivo applications.

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Citations

Nov 2, 2019·Analytical Chemistry·Xu-Dong Wang, Otto S Wolfbeis
Jul 23, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Siamak BeyranvandMohsen Adeli

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Methods Mentioned

BETA
biosensors
atomic force microscopy
transmission electron microscopy
AFM
confocal microscopy
biosensor

Software Mentioned

COMSOL

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