PMID: 3749790Sep 1, 1986Paper

Improved diagnosis of primary hyperparathyroidism by defining the inverse relationship between serum immunoreactive parathyroid hormone and calcium

Scandinavian Journal of Clinical and Laboratory Investigation
J F HalvorsenK M Gautvik

Abstract

Serum concentrations of immunoreactive parathyroid hormone (iPTH) measured with a mid-region specific radioimmunoassay and total calcium were correlated in 300 healthy subjects and 158 patients with surgically verified primary hyperparathyroidism (HPT). All the healthy individuals could be separated from the patients by a monoexponential declining curve in which iPTH at concentrations of 0.60 micrograms/l and 0.33 micrograms/l corresponded to calcium concentrations of 2.20 mmol/l and 2.60 mmol/l, respectively. In 22 patients more than one sample was analysed and serum iPTH and calcium were inversely correlated. In contrast, three patients with parathyroid carcinoma showed no reciprocal fluctuations between serum iPTH and calcium. Of 75 patients with hypercalcaemia due to malignant diseases (metastatic mammary carcinoma, bronchial carcinoma, renal carcinoma, myelomatosis), 62 had a normal iPTH/calcium relationship. Two patients with myelomatosis had a temporary elevation of serum iPTH and calcium due to renal impairment. One patient with bronchial carcinoma probably had ectopic production of iPTH. The remaining 10 patients (six mammary carcinomas and four bronchial carcinomas) were found in the pathological iPTH/calcium range. I...Continue Reading

References

Mar 1, 1978·The Journal of Clinical Endocrinology and Metabolism·A E BroadusF C Bartter
Jan 5, 1978·The New England Journal of Medicine·J FreitagE Slatopolsky
Aug 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R Bouillon, P de Moor
Apr 1, 1979·The Journal of Clinical Endocrinology and Metabolism·E M BrownG D Aurbach
Sep 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·K M GautvikR Tollman
Aug 1, 1978·The Journal of Clinical Investigation·J F Habener
Feb 1, 1978·The Journal of Clinical Endocrinology and Metabolism·E M BrownG D Aurbach
Jul 1, 1977·The Journal of Clinical Endocrinology and Metabolism·M E BirnbaumerL M Sherwood
Sep 1, 1977·Clinical Endocrinology·S E PapapoulosJ L O'riordan
May 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·P FauchaldK M Gautvik
Jul 1, 1972·Clinical Endocrinology·T M MurrayJ T Potts
May 1, 1971·The American Journal of Medicine·E Reiss, J M Canterbury
Jan 1, 1971·The Journal of Clinical Investigation·C D ArnaudT Littledike
May 1, 1971·The American Journal of Medicine·J T PottsL J Deftos
May 1, 1971·The American Journal of Medicine·L M SherwoodA Seyfer
Jul 1, 1968·The Journal of Clinical Endocrinology and Metabolism·S A Berson, R S Yalow
Oct 1, 1969·Archives of Internal Medicine·L M SherwoodC A Bassett
Jan 1, 1984·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·K M GautvikV T Gautvik
Jan 1, 1980·Contributions to Nephrology·R S Yalow

❮ Previous
Next ❯

Citations

Mar 2, 2021·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Matthew Philip DaviesSaba P Balasubramanian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Bronchogenic

Bronchogenic Carcinoma is a malignant lung cancer arising in the epithelium of the bronchus or bronchiole. Discover the latest research on Bronchogenic Carcinoma here.