Improved diagnostic clarity in shrimp allergic non-dust-mite sensitized patients

Allergy and Asthma Proceedings
Karen Thursday S TuanoCarla M Davis

Abstract

Allergen specific immunoglobulin E (sIgE) levels predictive of shrimp allergy have not been identified, but these may be helpful in identifying patients at risk for shrimp-induced allergic reactions. This study sought to identify component resolved diagnostic tests useful for diagnosis of shrimp allergy in patients with or without house-dust mite (HDM) sensitization to the major allergen cysteine protease (Der p 1). Patients with positive skin-prick test (SPT) results and/or sIgE values were recruited. Shrimp allergy was classified by oral food challenge (OFC) or by a clear history of anaphylaxis after shrimp ingestion. Patients with shrimp allergy and patients who were tolerant were further classified based on HDM sensitivity (Der p 1 > 0.35 kUA/L). Testing for sIgE to total shrimp, and shrimp and HDM components was performed. The Fisher exact test, Wilcoxon sum rank test, and receiver operating characteristics analyses were used to compare sIgE levels in patients with allergy and patients who were tolerant. Of 79 patients recruited, 12 patients with shrimp allergy (7 with positive OFC results and 5 with a history of anaphylaxis) and 18 patients who were shrimp tolerant were enrolled. Of the patients not HDM sensitized, sIgE l...Continue Reading

Citations

Mar 7, 2020·International Journal of Immunopathology and Pharmacology·Natalia Ukleja-SokołowskaZbigniew Bartuzi
Mar 18, 2020·The World Allergy Organization Journal·UNKNOWN Steering Committee Authors, UNKNOWN Review Panel Members
Jan 18, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Carla M DavisAndreas L Lopata
Oct 17, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Diem-Tran I NguyenCarla M Davis

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