Improved efficacy of naproxen-loaded NLC for temporomandibular joint administration

Scientific Reports
Viviane A GuilhermeEneida de Paula

Abstract

Inflammatory conditions of the temporomandibular joint (TMJ) and peripheral tissues affect many people around the world and are commonly treated with non-steroidal anti-inflammatory drugs (NSAIDs). However, in order to get desirable results, treatments with NSAIDs may take weeks, causing undesirable side effects and requiring repeated administration. In this sense, this work describes the development of an optimized nanostructured lipid carrier (NLC) formulation for intra-articular administration of naproxen (NPX). An experimental design (23) selected the best formulation in terms of its physicochemical and structural properties, elucidated by different methods (DLS, NTA, TEM, DSC, and ATR-FTIR). The chosen formulation (NLC-NPX) was tested on acute inflammatory TMJ nociception, in a rat model. The optimized excipients composition provided higher NPX encapsulation efficiency (99.8%) and the nanoparticles were found stable during 1 year of storage at 25 °C. In vivo results demonstrated that the sustained delivery of NPX directly in the TMJ significantly reduced leukocytes migration and levels of pro-inflammatory cytokines (IL-1β and TNF-α), for more than a week. These results point out the NLC-NPX formulation as a promising candi...Continue Reading

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Citations

Jan 10, 2021·Pharmaceutics·Daniela Placha, Josef Jampilek
Dec 7, 2020·Clinical and Experimental Dental Research·Gianluca Martino TartagliaStephen Thaddeus Connelly
Jul 1, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Vamshi Krishna RapalliGautam Singhvi
May 6, 2021·Biomaterials Science·Gustavo H Rodrigues da SilvaEneida de Paula
May 20, 2021·Biomaterials·Nadim AhamadRinti Banerjee
May 17, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marcela Tavares LuizDelia Rita Tapia-Blácido
Aug 18, 2021·Journal of Stomatology, Oral and Maxillofacial Surgery·Florent BarryRomain Nicot
Aug 21, 2021·Current Pharmaceutical Design·Sana KalaveAmbikanandan Misra

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Methods Mentioned

BETA
Dynamic Light Scattering
infrared spectroscopy
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

KinetDS
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