Improved equation for estimating single-pool Kt/V at higher dialysis frequencies.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
John T DaugirdasFHN Trial Group

Abstract

To measure adequacy in patients dialyzed other than three times per week, guidelines recommend the use of 'standard' Kt/V, which commonly is estimated from treatment Kt/V, time and frequency; however, the accuracy of equations that predict treatment Kt/V in patients being dialyzed other than three times per week has not been evaluated. In patients enrolled in the Frequent Hemodialysis Network (FHN) Daily and Nocturnal Trials who were being dialyzed three, four or six times per week, we tested the accuracy of the following Kt/V prediction equation: Kt/V = -ln(R - GFAC × T_hours) + (4-3.5 × R) × 0.55 × weight loss/V, where R = post-dialysis/pre-dialysis blood urea nitrogen and GFAC, originally set to 0.008 for a 3/week schedule (Daugirdas, J Am Soc Nephrol 1993), is a factor that adjusts for urea generation. With the above equation, there was <0.1% mean error in predicted treatment Kt/V for 3/week patients, but mean errors were -5, -9 and -13% for the 6/week daily, 4/week nocturnal and 6/week nocturnal patients. Modeling simulations were performed to optimize the GFAC term for dialysis schedule and length of the preceding interdialysis interval (PIDI). After substituting schedule- and interval-optimized GFAC terms, the treatment ...Continue Reading

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Citations

Nov 6, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Daljit K HothiElizabeth Harvey
Sep 10, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·James Tattersall
Feb 13, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yoshitsugu ObiKamyar Kalantar-Zadeh
May 18, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Angelito A BernardoBruce F Culleton
Aug 21, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Malgorzata DebowskaJacek Waniewski
May 14, 2016·Journal of the American Society of Nephrology : JASN·Yoshitsugu ObiKamyar Kalantar-Zadeh
Oct 27, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN National Kidney Foundation
Feb 9, 2017·American Journal of Nephrology·Qichen FanHuihua Pang
Jan 10, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco Gaetano Casino, Carlo Basile
Nov 14, 2017·American Journal of Nephrology·Christina CatabayKamyar Kalantar-Zadeh
Jan 13, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Matthew B RivaraRajnish Mehrotra
Nov 8, 2019·Hemodialysis International·Troy J PlumbMichael A Aragon
Apr 25, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mengjing WangKamyar Kalantar-Zadeh
Feb 23, 2019·Journal of Surgical Case Reports·Tsukasa NakamuraHidetaka Ushigome
Jan 9, 2016·The International Journal of Artificial Organs·Jan Sternby, John T Daugirdas
Aug 9, 2019·Journal of Nephrology·Francesco Gaetano CasinoCarlo Basile
Jan 6, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Linda DingMaury N Pinsk
Feb 3, 2021·Seminars in Dialysis·Thierry Petitclerc, Christophe Ridel

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