Improved exercise performance and skeletal muscle strength after simulated altitude exposure: a novel approach for patients with chronic heart failure

Journal of Cardiac Failure
Omar SaeedSimon Maybaum

Abstract

Adaptation to altitude leads to beneficial physiologic changes that improve oxygen delivery and utilization by the periphery. Athletes have used simulated altitude enclosures as part of their training regimen to improve exercise performance. We hypothesized that changes due to acclimatization would also be beneficial for patients with heart failure (HF). We report the results of a pilot study of altitude exposure in patients with chronic HF. Subjects with chronic stable HF, left ventricular ejection fraction (LVEF) ≤35%, on optimal medical therapy were enrolled and underwent simulated altitude exposure for 10 sessions, each 3-4 hours, over a period of 22 days. Starting altitude was 1,500 m and was increased by 300 m with each subsequent session to a maximum altitude of 2,700 m. Peak oxygen consumption, 6-minute walk distance (6MW), skeletal muscle strength, quality of life scores, LVEF, and hematologic parameters were measured at baseline and 48 hours and 4 weeks after the final session. Twelve subjects (median age 52.5 y, ejection fraction 31.7%) successfully completed the protocol without any adverse effects. Peak oxygen consumption significantly improved after altitude sessions from 13.5 ± 1.8 to 14.2 ± 1.9 mL kg(-1) min(-1)...Continue Reading

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Citations

Jun 26, 2013·High Altitude Medicine & Biology·Piergiuseppe Agostoni
Feb 3, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ju-Gyeong KangPaul M Hwang
Mar 16, 2017·High Altitude Medicine & Biology·Callum James Riley, Matthew Gavin
Jun 12, 2020·European Journal of Applied Physiology·Nattha MuangritdechApiwan Manimmanakorn
Jan 7, 2020·American Journal of Alzheimer's Disease and Other Dementias·Hong WangPeijie Chen
Sep 27, 2019·Respiratory Physiology & Neurobiology·Xiaoli LiuXiangrong Shi
Apr 1, 2021·Rejuvenation Research·Shraddha M KamatJames W Larrick
Apr 17, 2021·Ageing Research Reviews·Johannes BurtscherGrégoire P Millet

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