Improved Exercise Tolerance with Caffeine Is Associated with Modulation of both Peripheral and Central Neural Processes in Human Participants

Frontiers in Nutrition
Joanna L BowtellK N Mileva

Abstract

Caffeine has been shown to enhance exercise performance and capacity. The mechanisms remain unclear but are suggested to relate to adenosine receptor antagonism, resulting in increased central motor drive, reduced perception of effort, and altered peripheral processes such as enhanced calcium handling and extracellular potassium regulation. Our aims were to investigate how caffeine (i) affects knee extensor PCr kinetics and pH during repeated sets of single-leg knee extensor exercise to task failure and (ii) modulates the interplay between central and peripheral neural processes. We hypothesized that the caffeine-induced extension of exercise capacity during repeated sets of exercise would occur despite greater disturbance of the muscle milieu due to enhanced peripheral and corticospinal excitatory output, central motor drive, and muscle contractility. Nine healthy active young men performed five sets of intense single-leg knee extensor exercise to task failure on four separate occasions: for two visits (6 mg·kg-1caffeine vs placebo), quadriceps31P-magnetic resonance spectroscopy scans were performed to quantify phosphocreatine kinetics and pH, and for the remaining two visits (6 mg·kg-1caffeine vs placebo), femoral nerve elect...Continue Reading

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Citations

Feb 25, 2020·Experimental Physiology·Ricardo N O MesquitaJanne Avela
Apr 7, 2020·International Journal of Sports Medicine·Andrew T HultonDon P M MacLaren
Jun 10, 2020·Journal of the International Society of Sports Nutrition·Andreas ApostolidisMarios Hadjicharalambous
May 15, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Pamela S SantosAdriano E Lima-Silva
Oct 22, 2020·Brain Sciences·Claudia V TurcoAimee J Nelson
Dec 4, 2020·Journal of Applied Physiology·James L NuzzoJanet L Taylor
Jan 4, 2021·Journal of the International Society of Sports Nutrition·Nanci S GuestBill I Campbell
Apr 1, 2021·International Journal of Sports Physiology and Performance·Ana C Santos-MarianoAdriano E Lima-Silva

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