Improved fracture prediction using different fracture risk assessment tool adjustments in HIV-infected women.

AIDS
Jingyan YangMichael T Yin

Abstract

A fracture risk assessment tool (FRAX) using clinical risk factors (CRFs) alone underestimates fracture risk in HIV-infected men. Our objective was to determine whether accuracy of FRAX would be improved by considering HIV as a cause of secondary osteoporosis, and further improved with addition of dual-energy X-ray absorptiometry parameters in HIV-infected women. Subgroup analysis of Women's Interagency HIV Study. We included 1148 women (900 HIV-infected and 248 uninfected) over age 40 with data to approximate FRAX CRFs and 10-year observational data for incident fragility fractures; 181 (20%) HIV-infected women had dual-energy X-ray absorptiometry data. Accuracy of FRAX was evaluated by the observed/estimated ratios of fracture in four models: CRFs alone; CRFs with HIV included as a cause of secondary osteoporosis; CRFs and femoral neck bone mineral density (FN BMD); and CRFs, FN BMD and trabecular bone score. FRAX using CRFs were less accurate in HIV-infected than uninfected women for major osteoporotic (observed/estimated ratio: 5.05 vs. 3.26, P < 0.001) and hip fractures (observed/estimated ratio: 19.78 vs. 7.94, P < 0.001), but improved when HIV was included as a cause of secondary osteoporosis. Among HIV-infected women, F...Continue Reading

References

Mar 21, 1998·Epidemiology·S E BarkanJ Feldman
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Rouillard, N E Lane
Sep 2, 2003·Gastroenterology·William D LeslieUNKNOWN American Gastroenterological Association Clinical Practice Commitee
Apr 20, 2004·AIDS·Sara E DolanSteven Grinspoon
Dec 24, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·John A KanisNikolai Khaltaev
Jul 12, 2005·Current Medical Research and Opinion·Craig D Rubin
Sep 9, 2005·Clinical and Diagnostic Laboratory Immunology·Melanie C BaconMary A Young
Feb 7, 2009·Bone·John A KanisEugene McCloskey
Oct 31, 2009·The Journal of Infectious Diseases·Alexandra CalmyAndrew Carr
Nov 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael T YinKathryn Anastos
Mar 2, 2011·PloS One·Julie A WomackUNKNOWN Veterans Aging Cohort Study Project Team
Mar 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin YoungUNKNOWN HIV Outpatient Study (HOPS) Investigators
Jul 5, 2011·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Didier HansMarc-Antoine Krieg
Sep 3, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Didier HansWilliam D Leslie
Nov 5, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lora M GiangregorioJohn A Kanis
May 24, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincent Lo ReA Russell Localio
Aug 17, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anjali SharmaPhyllis C Tien
Mar 6, 2013·Calcified Tissue International·Michael T YinElizabeth Shane
May 1, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Todd T Brown
Jul 23, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Masayuki IkiHideo Yoneshima
Jan 21, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Barbara C SilvaJohn P Bilezikian
Jun 22, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W D LeslieD Hans
Aug 30, 2014·Endocrinology and Metabolism Clinics of North America·Juliet Compston
Jan 23, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Todd T BrownWilliam G Powderly
Mar 11, 2015·The Journal of Infectious Diseases·Vincent Lo ReMary B Leonard
Mar 23, 2015·Calcified Tissue International·Eugene V McCloskeyJohn A Kanis
Jun 13, 2015·The Journal of the Association of Nurses in AIDS Care : JANAC·Yamnia I CortésNancy K Reame
Jul 4, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V V ZhukouskayaI Chiodini
Jul 22, 2015·Antiviral Therapy·Linda BattaloraUNKNOWN HIV Outpatient Study (HOPS) and SUN Study Investigators
Sep 1, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anjali SharmaMichael T Yin
Oct 27, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eugene V McCloskeyJohn A Kanis
Feb 19, 2016·Current Opinion in HIV and AIDS·Roger BedimoVincent Lo Re
Feb 27, 2016·Current Opinion in HIV and AIDS·Michael T Yin, Julian Falutz
Mar 24, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael T YinJulie A Womack
Jun 9, 2016·Journal of Internal Medicine·J Compston
Jun 25, 2016·Australian Prescriber·Angela Sheu, Terry Diamond
Feb 25, 2017·Journal of Bone and Mineral Metabolism·Lorenzo CiulliniF G Conti
Nov 18, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roger J BedimoNaim M Maalouf

❮ Previous
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Citations

Nov 13, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Berend J van WelzenTania Mudrikova
Dec 7, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jakob Starup-LindeBente Langdahl
Feb 1, 2019·AIDS·Anjali SharmaMichael T Yin
Aug 18, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F GuoE Hsieh
Mar 25, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M O Premaor, J E Compston
Apr 15, 2020·Current Osteoporosis Reports·William D Leslie, Suzanne N Morin
Jan 4, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lauren F CollinsIghovwerha Ofotokun
Oct 16, 2021·Journal of Neuroendocrinology·Mohammed F SalahuddinJason J Paris

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