Improved gas chromatographic-mass spectrometric method for the quantitative determination of vinpocetine in human plasma

Journal of Chromatography. B, Biomedical Sciences and Applications
M VatsovaN Tyutyulkova

Abstract

An improved and validated method for the determination of vinpocetine in human plasma using a combination of a solid-phase extraction as a cleaning step followed by gas chromatography-mass spectrometry (GC-MS) has been presented. Quantitation has been carried out with apovincaminic acid methyl ester as internal standard. A limit of detection of 0.01 ng/ml, limit of quantitation of 0.10 ng/ml, as well as a satisfactory accuracy, improved precision and prolonged capillary column life have been achieved.

References

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