Improved gastrointestinal health for irritable bowel syndrome with metagenome-guided interventions.

Precision Clinical Medicine
Cem MeydanBodi Zhang

Abstract

Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal disorder worldwide, and the most common reason for referral to gastroenterology clinics. However, the pathophysiology is still not fully understood and consequently current management guidelines are very symptom-specific, leading to mixed results. Here we present a study of 88 individuals with IBS who had baseline sequencing of their gut microbiome (stool samples), received targeted interventions that included dietary, supplement, prebiotic/probiotic, and lifestyle recommendations for a 30-day period, and a follow-up sequencing of their gut microbiome. The study's objectives were to demonstrate unique metagenomic signatures across the IBS phenotypes and to validate whether metagenomic-guided interventions could lead to improvement of symptom scores in individuals with IBS. Enrolled subjects also completed a baseline and post-intervention questionnaire that assessed their symptom scores. The average symptom score of an individual with IBS at baseline was 160 and at the endpoint of the study the average symptom score of the cohort was 100.9. The mixed IBS subtype showed the most significant reduction in symptom scores across the different subtypes (a...Continue Reading

References

Jan 11, 1992·BMJ : British Medical Journal·R Jones, S Lydeard
Mar 1, 1996·Gastroenterology Clinics of North America·G R Locke
Jun 16, 2001·The New England Journal of Medicine·B J Horwitz, R S Fisher
May 10, 2003·The American Journal of Gastroenterology·Nicholas J Talley
Dec 21, 2004·Alimentary Pharmacology & Therapeutics·D Lesbros-PantoflickovaA L Blum
Aug 25, 2006·The American Journal of Gastroenterology·Heather A HalvorsonMark S Riddle
Jul 21, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S D DornA J Lembo
Jan 27, 2010·Nature Reviews. Gastroenterology & Hepatology·Lena Ohman, Magnus Simrén
Nov 26, 2010·Current Opinion in Gastroenterology·Joseph Y Chang, Nicholas J Talley
Jul 9, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ian M CarrollYehuda Ringel
Jul 12, 2011·Gastroenterology·Delphine M SaulnierJames Versalovic
Feb 22, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I M CarrollY Ringel
Mar 20, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rebecca M Lovell, Alexander C Ford
Mar 29, 2012·Genome Biology·Christopher E Mason, Olivier Elemento
Jun 13, 2012·Nature Methods·Nicola SegataCurtis Huttenhower
Jun 22, 2012·PLoS Computational Biology·Sahar AbubuckerCurtis Huttenhower
Mar 2, 2013·Clinics in Colon and Rectal Surgery·Kaitlin Occhipinti, James W Smith
Apr 4, 2013·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·María Ortiz-LucasJuan José Sebastián
Mar 4, 2014·Genome Biology·Derrick E Wood, Steven L Salzberg
Mar 18, 2015·World Journal of Gastroenterology : WJG·Tina DidariMohammad Abdollahi
Apr 29, 2015·Gut and Liver·Sean M P BennetMagnus Simren
Sep 30, 2015·Nature Methods·Duy Tin TruongNicola Segata
Feb 24, 2016·World Journal of Gastroenterology : WJG·Eleonora DistruttiStefano Fiorucci
May 5, 2016·Gastroenterology·Fermín MearinRobin Spiller
Nov 15, 2016·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jennifer McKeanNatalie Colson
Feb 7, 2017·Gastroenterology Clinics of North America·Timothy G Dinan, John F Cryan
Feb 10, 2017·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hai-Ning LiuTao-Tao Liu
Aug 9, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·W-T FanB Gu
Feb 9, 2018·International Journal of Preventive Medicine·Helia Pourmand, Ahmad Esmaillzadeh
Mar 3, 2018·Advances in Therapy·Bruno K Rodiño-JaneiroJavier Santos
Aug 10, 2018·Frontiers in Microbiology·Xiaojun ZhuangLishou Xiong
Nov 1, 2018·Nature Methods·Eric A FranzosaCurtis Huttenhower
Nov 18, 2018·Genome Biology·F P BreitwieserS L Salzberg
Apr 13, 2019·Science·Francine E Garrett-BakelmanFred W Turek
Jul 10, 2019·Precision Clinical Medicine·Anthony J Bilotta, Yingzi Cong

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Citations

Dec 18, 2020·Current Opinion in Gastroenterology·Teodora Surdea-BlagaDan Lucian Dumitraşcu
Feb 2, 2021·Frontiers in Pharmacology·Rajeev K SinglaGokhan Zengin

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Methods Mentioned

BETA
whole
amplicon sequencing
PCR

Software Mentioned

Enteromend
MetaPhlAn2

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