Improved Glucose and Lipid Metabolism in the Early Life of Female Offspring by Maternal Dietary Genistein Is Associated With Alterations in the Gut Microbiota

Frontiers in Endocrinology
Liyuan ZhouRongrong Li

Abstract

Maternal over-nutrition can lead to metabolic disorders in offspring, whereas maternal dietary genistein may have beneficial effects on the metabolic health of offspring. Our objective was to determine whether maternal dietary genistein could attenuate the detrimental effects of a maternal high-fat diet on their offspring's metabolism and to explore the role of the gut microbiota on their offspring's glucose and lipid metabolism. C57BL/6 female mice were fed either a high-fat diet without genistein (HF), high-fat diet with low-dose genistein (0.25 g/kg diet) (HF.LG), high-fat diet with high-dose genistein (0.6 g/kg diet) (HF.HG) or normal control diet (Control) for 3 weeks prior to breeding and throughout gestation and lactation. The female offspring in the HF group had lower birth weights and glucose intolerance and higher serum insulin, triacylglycerol (TG) and total cholesterol (TC) levels at weaning compared with the Control group. Offspring from HF.LG dams had increased birth weight, improved glucose tolerance, and decreased fasting insulin, whereas the serum TG and TC levels were decreased in HF.HG offspring in comparison with HF offspring. The significant enrichment of Bacteroides and Akkermansia in offspring from genist...Continue Reading

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Citations

Jul 19, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Israel YolesTamar Wainstock
May 19, 2020·Molecular Ecology·Taichi A SuzukiMichael W Nachman
Apr 25, 2020·Nutrients·Yolanda Gálvez-OntiverosAna Rivas
Jan 22, 2021·Journal of Developmental Origins of Health and Disease·Israel YolesTamar Wainstock
Jul 26, 2021·European Journal of Pharmacology·Jiang-Nan SunLi-Ying Qiu
Aug 24, 2021·Current Opinion in Endocrine and Metabolic Research·Cheryl S Rosenfeld
Jan 18, 2022·Applied Microbiology and Biotechnology·Feng JiangTongzuo Zhang

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Datasets Mentioned

BETA
SRP156380

Methods Mentioned

BETA
ELISA
PCR
gastric bypass

Software Mentioned

ANOSIM
UPARSE
GraphPad
R
Prism
MetaStat
QIIME
LEfSe

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