PMID: 18714676Aug 22, 2008Paper

Improved glucose regulation on a low carbohydrate diet in diabetic rats transplanted with macroencapsulated porcine islets

Cell Transplantation
Horatiu V VinereanBarry H Smith

Abstract

Islet xenografts from porcine donors can reverse diabetes in experimental animal models and may be an alternative to human islet transplantation. We have recently reported the ability of porcine islets encapsulated in a double layer of hydrophilic agarose to maintain in vitro functional ability for >6 months. Although beta-cells are capable of adapting their secretory capacity in response to glucose levels, evidence has shown that prolonged hyperglycemia can compromise this ability. The aim of the present study was to determine the effects of diet manipulation on the long-term regulation of blood glucose levels, and the preservation of functional islet in the macrobeads. Twenty-one streptozotocin-induced diabetic Wistar-Furth male rats were randomly assigned to two diets containing 64% carbohydrate (CHO) or 20% CHO. Groups of five to six animals assigned to either diet were implanted with either empty (EM) or porcine islet-containing macrobeads (PIM) and followed for 333 days. Observations included general condition, body weight, blood glucose, and food and water intakes. Monthly blood samples were collected for insulin and C-peptide analysis. The 20% CHO diet significantly lowered blood glucose values when compared with those ...Continue Reading

References

Jan 15, 1982·Experientia·A F Bleasel, L C Yong
May 11, 1994·JAMA : the Journal of the American Medical Association·A GargB A Huet
Jun 1, 1997·Journal of the Royal Society of Health·M BladesJ W Dickerson
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Dec 16, 1998·Journal of the American College of Nutrition·M GutierrezC M Peterson
Feb 11, 2003·Physiology & Behavior·Ahmed BensaïdGilles Fromentin

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Citations

May 21, 2015·Journal of Zhejiang University. Science. B·Hai-tao ZhuBo Wang
Feb 6, 2017·Cell Transplantation·Zhengzhao LiuLisha Mou

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