Abstract
To determine whether combination oral hypoglycemic therapy in insulin-using patients with non-insulin-dependent diabetes mellitus (NIDDM) can improve glycemic control for a prolonged period. We expanded and extended an earlier study to include 130 patients with NIDDM for 10 to 30 years who had been using twice-daily mixed insulin for less than 10 years. Reduction and eventual elimination of the insulin therapy and substitution of metformin and a sulfonylurea were attempted. At follow-up visits, patients were weighed, random plasma glucose levels were determined, and glycosylated hemoglobin values were obtained. Of 130 C-peptide-positive patients with NIDDM receiving twice-daily mixed insulin, 100 were successfully transferred to combination oral hypoglycemic therapy with glyburide originally and later glimepiride and metformin--a primary failure rate of 23.1%. Secondary failure occurred in 20 patients after a mean duration of 6.4 months. Two patients with successful conversion to oral combination therapy resumed insulin treatment because of cost. Of the patients with primary failures, 6 had gastrointestinal side effects, 10 were successfully managed on combination oral therapy plus evening mixed insulin, and 14 ultimately recei...Continue Reading
References
Mar 1, 1992·The American Journal of the Medical Sciences·M RiddleP McDaniel
Jun 1, 1992·Diabetes Care·C J Bailey
Nov 2, 1989·The New England Journal of Medicine·J E Gerich
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·A M Bonser, P Garcia-Webb
Aug 31, 1995·The New England Journal of Medicine·R A DeFronzo, A M Goodman
Jul 1, 1993·Baillière's Clinical Endocrinology and Metabolism·J E Gerich
Jan 1, 1993·European Journal of Clinical Pharmacology·D GiuglianoF D'Onofrio
Mar 1, 1997·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D S Bell, M S Mayo
Citations
Jun 15, 2011·Cellular and Molecular Life Sciences : CMLS·Diethart SchmidThomas Moeslinger
Feb 19, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·A G Jones, A T Hattersley
Aug 14, 2002·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·David S H Bell, Fernando Ovalle
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D S Bell, M S Mayo
Mar 10, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D S Bell, F Ovalle
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D S Bell, F Ovalle
Aug 18, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·David S H Bell
Oct 1, 2021·Diabetologia·Richard I G HoltAnne L Peters
Oct 2, 2021·Diabetes Care·Richard I G HoltAnne L Peters