Feb 26, 1976

Improved histological localization of GABA-transaminase activity in rat cerebellar cortex after aldehyde fixation

J C Hyde, N Robinson


A method for the chemical fixation of the enzyme GABA-transaminase in nervous tissue is described. It is shown that after perfusion with a formaldehyde/glutaraldehyde fixative, activity of the enzyme in cerebellar cortex is demonstrable whilst cellular morphology is preserved. Results from the improved technique have shown new sites of GABA-transaminase activity in cerebellar cortex. In view of these results a special function for glial cells in this area of brain has been suggested.

Mentioned in this Paper

Establishment and Maintenance of Localization
Neural Inhibition
Purkinje Cells
Sample Fixation
ABAT gene
Biologic Preservation

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