PMID: 15379023Sep 24, 2004Paper

Improved image contrast of calcifications in breast tissue specimens using diffraction enhanced imaging

Physics in Medicine and Biology
Miklos Z KissEtta Pisano

Abstract

The contrast of calcifications in images of breast tissue specimens using a synchrotron-based diffraction enhanced imaging (DEI) apparatus has been measured and is compared to the contrast in images acquired using a conventional synchrotron-based radiographic imaging modality. DEI is an imaging modality which derives image contrast from x-ray absorption, refraction and small-angle scatter-rejection (extinction), unlike conventional radiographic techniques, which can only derive contrast from absorption. DEI is accomplished by inserting an analyser crystal in the beam path between the sample and the detector. Two of the three breast tissue specimens contained calcifications associated with cancer, while a third contained benign calcifications. Results of the image analysis indicate that the DEI contrast of images taken with the analyser crystal tuned to the peak of its rocking curve, was as much as 19 times that of the conventional radiograph, with an average of 5.5 for all calcifications. This improved image contrast for even near-pixel-size calcifications suggests potential utility for DEI in breast imaging.

References

Oct 1, 1991·Radiology·J T SurrattG Mazoujian
Nov 1, 1988·Radiology·A Fandos-MoreraA Traveria-Cros
Nov 1, 1988·Radiology·S L OlsonS E Gordon
Mar 1, 1982·Investigative Radiology·B M GalkinK E Holderness
Nov 1, 1994·Radiology·S H ParkerP R Garver
Mar 1, 1994·Investigative Radiology·F E CarrollG Reed
Aug 1, 1997·Physics in Medicine and Biology·A R CowenD S Brettle
Dec 12, 1997·Physics in Medicine and Biology·D ChapmanD Sayers
Sep 15, 1998·IEEE Transactions on Medical Imaging·H D ChengR I Freimanis
Dec 9, 1998·IEEE Transactions on Medical Imaging·T C Wang, N B Karayiannis
Sep 30, 1999·IEEE Transactions on Medical Imaging·G M te Brake, N Karssemeijer
Nov 26, 1999·IEEE Transactions on Medical Imaging·T Netsch, H O Peitgen
Feb 5, 2000·Medical Physics·M A GavrielidesC E Floyd
Jun 23, 2001·Physics in Medicine and Biology·A BazzaniD Romani
Mar 1, 2003·Physics in Medicine and Biology·Miklos Z KissZhong Zhong
Jul 30, 2003·Physics in Medicine and Biology·P Suortti, W Thomlinson

❮ Previous
Next ❯

Citations

Jan 14, 2010·International Journal of Biomedical Imaging·Adam B NoverAri D Brooks
Oct 18, 2006·Zoological Science·Eiko HashimotoMasami Ando
Oct 2, 2009·The Review of Scientific Instruments·Ivan NeschDean Chapman
Feb 6, 2013·Zeitschrift für medizinische Physik·Gisela AntonLukas Wucherer
Jun 27, 2012·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Donepudi V RaoGiovanni E Gigante
Oct 1, 2011·Academic Radiology·Dean M ConnorEtta D Pisano
May 4, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Donepudi V RaoGiovanni E Gigante
Apr 21, 2009·Academic Radiology·Christopher ParhamEtta D Pisano
Jul 8, 2008·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Shu-Ang Zhou, Anders Brahme
Jun 8, 2006·Physics in Medicine and Biology·D M ConnorZ Zhong
Mar 22, 2007·Physics in Medicine and Biology·Cheng-Ying ChouZhong Zhong
Jul 21, 2005·Physics in Medicine and Biology·Dahliyani BriedisRob A Lewis
Apr 5, 2013·Physics in Medicine and Biology·Thilo MichelAndrea Zang
Mar 11, 2020·Journal of Synchrotron Radiation·Akio YoneyamaMasahide Kawamoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.