Improved immunogenicity of a novel third-generation recombinant hepatitis B vaccine in patients with end-stage renal disease

Nephron. Clinical Practice
Talia WeinsteinUzi Gafter

Abstract

Hepatitis B (HBV) infection remains a significant epidemiological problem in the end-stage renal disease (ESRD) population. Vaccination programs using second-generation vaccines lead to effective seroprotection in only 50-60% of these patients. The purpose of this case series was to describe our experience with a novel third-generation vaccine, Bio-Hep-B, in ESRD patients who had not developed protective anti-HBs titers following a second-generation HBV vaccination protocol. Twenty-nine ESRD patients who had not responded in the past to a standard second-generation HBV vaccination protocol were included in this series. Each patient received 10 microg of Bio-Hep-B) intramuscularly at 0, 1 and 6 months. A month after completion of the vaccination protocol, anti-HBs antibody levels were measured. Following immunization, 25 of 29 patients (86%) developed seroprotective anti-HBs levels > or =10 mIU/ml. There was a significant difference in the titers of anti-HBs antibodies prior to and following vaccination (p < 0.0001). Statistical analysis of the variables age, gender, diagnosis, dialysis mode, weight, hemoglobin, albumin, and KT/V failed to detect predictors of antibody response. A retrospective analysis of the results of a secon...Continue Reading

Citations

Apr 21, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Adriana WeinbergElizabeth T Golub
Oct 26, 2005·Journal of Gastroenterology and Hepatology·Ping-Nam WongAndrew Km Wong
May 18, 2010·Nephrology·Matthew EdeyDavid W Johnson
Jan 11, 2014·Expert Review of Vaccines·Roy MathewJeffrey S Kennedy
Aug 26, 2014·Expert Review of Vaccines·Alicja E Grzegorzewska
Feb 23, 2008·La Presse médicale·Nabil Ben ChaabaneHammouda Saffar
Mar 22, 2007·Alimentary Pharmacology & Therapeutics·E O MoraisL J da Silva
Jul 4, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P FriedrichN Babel
May 20, 2015·Journal of Pediatric Gastroenterology and Nutrition·Merav Heshin-BekensteinAri Silbermintz
Jan 6, 2015·Medical Microbiology and Immunology·Daniel ShouvalMichael Roggendorf
Sep 15, 2016·Journal of Travel Medicine·Jason A TrubianoJoseph Torresi
May 10, 2018·Seminars in Dialysis·Georges KosmadakisDidier Aguilera
Sep 19, 2014·World Journal of Gastroenterology : WJG·Theodoros EleftheriadisIoannis Stefanidis
Nov 9, 2019·Journal of Nephrology·Suwasin UdomkarnjananunPaweena Susantitaphong
Jan 30, 2016·The International Journal of Artificial Organs·Fabrizio FabriziPiergiorgio Messa
Dec 8, 2015·World Journal of Gastroenterology : WJG·Sobia ManzoorJaved Ashraf
Jul 28, 2016·Wiener klinische Wochenschrift·Ursula WiedermannKarl Zwiauer
Jan 31, 2019·World Journal of Transplantation·Swati AroraKalathil K Sureshkumar
Jan 12, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Fabrizio FabriziEzequiel Ridruejo
Jun 26, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Fabrizio FabriziEzequiel Ridruejo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.