Improved liver function after portal vein embolization and an elective right hepatectomy

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Raphael P H MeierPietro E Majno

Abstract

Portal vein embolization (PVE) is used before extensive hepatic resections to increase the volume of the future remnant liver within acceptable safety margins (conventionally >0.6% of the patient's weight). The objective was to determine whether pre-operative PVE impacts on post-operative liver function independently from the increase in liver volume. The post-operative liver function of patients who underwent an anatomical right liver resection with (n = 28) and without (n = 53) PVE were retrospectively analysed. Donors of the right liver were also analysed (LD) (n = 17). Patient characteristics were similar, except for age, weight and American Society of Anesthesiologists (ASA) score that were lower in LD. Post-operative factor V and bilirubin levels were, respectively, higher and lower in patients with PVE compared with patients without PVE or LD (P < 0.05). Patients with PVE had an increased blood loss, blood transfusions and sinusoidal obstruction syndrome. The day-3 bilirubin level was 40% lower in the PVE group compared with the no-PVE group after adjustment for body weight, chemotherapy, operating time, Pringle time, blood transfusions, remnant liver volume, pre-operative bilirubin level and pre-operative prothrombin ra...Continue Reading

References

Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M NaginoH Yamamoto
Dec 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T de BaereV Bousson
Nov 15, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H HaradaS Kawasaki
Nov 15, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K KubotaT Takayama
Feb 12, 1998·Journal of Hepatology·K YamakadoY Kawarada
Mar 16, 2000·The British Journal of Surgery·K SeymourD M Manas
Jan 3, 2001·The British Journal of Surgery·G M EttorreJ Belghiti
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Rubbia-BrandtB Terris
Aug 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Yi ZhaoSheung Tat Fan
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Roberto TroisiBernard de Hemptinne
Mar 24, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Xiao XuChung Mau Lo
Apr 13, 2006·The British Journal of Surgery·K KomoriY Nimura
Apr 5, 2008·Journal of Hepatology·Panagiotis LainasIbrahim Dagher
Jul 23, 2008·Journal of Hepatology·Mickael Lesurtel, Jacques Belghiti
May 25, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Martin StockmannPeter Neuhaus
Jul 21, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M NinomiyaY Maehara
Apr 13, 2011·The British Journal of Surgery·W de GraafT M van Gulik
May 5, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ting-Jung WuWei-Chen Lee
Aug 15, 2013·Seminars in Liver Disease·Gilles MenthaPietro Majno
Dec 3, 2014·The Journal of Surgical Research·Maciej MalinowskiMartin Stockmann
Mar 3, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kristopher P CroomeDavid M Nagorney

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Citations

Sep 19, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Hong-Chuan ZhaoXiao-Ping Geng
Jun 16, 2017·Insights Into Imaging·Akshat GotraAn Tang

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