Improved lung function and symptom control with formoterol on demand in asthma

The European Respiratory Journal
D CheungOZON study group

Abstract

Many asthma patients remain symptomatic despite maintenance therapy with inhaled corticosteroids (ICS) and salbutamol as rescue medication. In the present study the relative efficacy and preference for as-needed formoterol compared with salbutamol was examined. In total, 211 patients with a mean age of 45 yrs (mean forced expiratory volume in one second (FEV1) 77% predicted normal), using ICS, were randomised to 3 weeks' double-blind treatment with as-needed formoterol 4.5 microg Turbuhaler and with as-needed salbutamol 100 mug Turbuhaler in a cross-over fashion. Overall, lung function and symptom control were better with as-needed formoterol than with as-needed salbutamol. During as-needed formoterol treatment daytime and night-time symptom scores were lower, peak expiratory flow and FEV1 were higher and patients experienced fewer disturbed nights (34%) compared with as-needed salbutamol. Patients preferred the formoterol treatment to salbutamol. Of the 162 patients expressing a preference, formoterol was preferred by 68% (95% confidence interval: 60-75). Subjective assessment of effectiveness also favoured formoterol, which was perceived as slightly faster acting than salbutamol. In conclusion, as-needed formoterol improved s...Continue Reading

Citations

Oct 7, 2010·Expert Review of Respiratory Medicine·David HodgsonTim Harrison
Jul 22, 2009·Expert Opinion on Drug Metabolism & Toxicology·Dennis KimRichard Lockey
Sep 9, 2010·The Cochrane Database of Systematic Reviews·Emma J Welsh, Christopher J Cates
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Christopher J Cates, Matthew J Cates
Dec 19, 2018·American Journal of Respiratory and Critical Care Medicine·J Michael RamsahaiPeter A B Wark
Apr 6, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Christiaan TheunisseDavid Cheung

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