PMID: 2495386Apr 1, 1989Paper

Improved lung preservation using a dimethylthiourea flush

The Journal of Surgical Research
D E PaullB R Wilcox

Abstract

The purpose of this study was to evaluate the ability of dimethylthiourea (DMTU), a low molecular weight hydroxyl free radical scavenger, to improve preservation of the lung for transplantation. Following preservation, 15 isolated canine left lower lobes were reperfused for 90 min with autologous blood. Five group I lobes served as controls and were not subjected to ischemia prior to reperfusion. Five group II lobes were flushed and submerged in a cold Euro-Collins solution and stored for 4 hr at 4 degrees C prior to reperfusion. Group III lobes were flushed with a 20 mM DMTU-enhanced Euro-Collins solution, stored for 4 hr, and then reperfused. The isogravimetric method was utilized to determine the capillary permeability coefficient (Kfc) for the reperfused lobes. The Kfc values were 0.10 +/- 0.01, 0.17 +/- 0.01, and 0.10 +/- 0.008 ml/min/mm Hg/100 g lung for groups I, II, and III, respectively (P less than 0.01 II vs I, III). Extravascular lung water values in the reperfused lobe were 4.44 +/- 0.45, 6.57 +/- 0.38, and 5.23 +/- 0.22 ml/g blood free dry lung weight for groups I, II, and III (P less than .05, II vs. I, III). Lung lipid peroxidation, measured as thiobarbituric acid-reactive material, was higher in group II, 146 +...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
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Apr 1, 1988·Mayo Clinic Proceedings·P A Southorn, G Powis
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Citations

Dec 1, 1990·Transplant International : Official Journal of the European Society for Organ Transplantation·G WangJ Pepper
May 1, 1994·Free Radical Biology & Medicine·C P LewisB Nemery
Mar 7, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S J RooneyR S Bonser
Jan 1, 1991·Acta Anaesthesiologica Scandinavica. Supplementum·B RisbergP Ortenwall
Aug 1, 1990·The Annals of Thoracic Surgery·F C DetterbeckB R Wilcox
Jun 1, 1993·The Annals of Thoracic Surgery·T M EganB R Wilcox
Apr 1, 1991·The Annals of Thoracic Surgery·N D KonS A Mills
Jun 11, 1991·The Annals of Thoracic Surgery·C J LambertB R Wilcox
Sep 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·C J LiuH Wada
Oct 17, 1998·Perception·I Giannopulu, J C Lepecq
Apr 9, 1991·Journal of Intensive Care Medicine·M I BiermanJ H Dauber
Oct 1, 1989·Current Problems in Surgery·T M EganJ D Cooper
May 1, 2015·Inorganic Chemistry·Arijit Singha HazariGoutam Kumar Lahiri

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