PMID: 590311Dec 2, 1977

Improved method for comparative evaluation of aldosterone antagonists in healthy man

European Journal of Clinical Pharmacology
J Casals-StenzelW Losert


A method of assessing the qualitative and quantitative activity of competitive aldosterone antagonists in healthy man is described. It requires intravenous infusion of aldosterone (0.5 mg/6 h), iv and oral water loading for six hours and fractionated collection of urine over eight hours. Aldosterone antagonists were administered orally 1.5 h before the start of the infusion (spironolactone 50, 200 or 800 mg) or added to the infused solution (potassium cnarenoate 300, 600 or 1000-1200 mg). The effect was assessed by changes in urinary sodium and potassium excretion and in urinary Na+/K+ ratio. The plasma levels and urinary excretion of canrenone, canrenoate and canrenoate ester glucuronide, respectively, were determined after administration of spironolactone and potassium canrenoate. Between 4-8 h (spironolactone) or 2-8 h (potassium canrenoate) after commencement of the infusion there was linear dose-dependent reversal of the mineralocorticoid-induced sodium retention and/or decrease in the Na+/K+ ratio. The plasma levels and urinary excretion of the metabolites measured were also dose-dependent. The method appears suitable for comparison of the potency of aldosterone antagonists and for defining the time course of drug action ...Continue Reading


Dec 29, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·U AbshagenG Luszpinski
Oct 1, 1975·Clinical Pharmacology and Therapeutics·L E RamsayM J Tidd
Feb 1, 1976·Clinical Pharmacology and Therapeutics·A KarimM Dooley
Feb 1, 1976·Clinical Pharmacology and Therapeutics·A KarimB J Baltes
Jul 3, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·W SadéeN Rietbrock
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·H C Erbler
May 1, 1974·Metabolism: Clinical and Experimental·D J Morris, R P Davis
Aug 1, 1974·Clinical Pharmacology and Therapeutics·W J MroczekF A Finnerty
Jul 1, 1972·Journal of Pharmaceutical Sciences·W SadéeS Riegelman
May 1, 1971·Journal of Pharmaceutical Sciences·A KarimH I Maibach
Nov 1, 1958·The Journal of Clinical Investigation·J T AUGUSTG W THORN
Mar 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·C M KAGAWAM L ANDERSON
Aug 1, 1976·British Journal of Clinical Pharmacology·L E RamsayM J Tidd


Apr 6, 2004·Journal of the American College of Cardiology·J FletcherJ N Townend

Related Concepts

Aldosterone, (+-)-Isomer
Mineralocorticoid Receptor Antagonists
Drug Evaluation
Spiro von ct

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.