Improved Method to Stratify Elderly Patients With Cancer at Risk for Competing Events

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Ruben CarmonaLoren K Mell

Abstract

To compare a novel generalized competing event (GCE) model versus the standard Cox proportional hazards regression model for stratifying elderly patients with cancer who are at risk for competing events. We identified 84,319 patients with nonmetastatic prostate, head and neck, and breast cancers from the SEER-Medicare database. Using demographic, tumor, and clinical characteristics, we trained risk scores on the basis of GCE versus Cox models for cancer-specific mortality and all-cause mortality. In test sets, we examined the predictive ability of the risk scores on the different causes of death, including second cancer mortality, noncancer mortality, and cause-specific mortality, using Fine-Gray regression and area under the curve. We compared how well models stratified subpopulations according to the ratio of the cumulative cause-specific hazard for cancer mortality to the cumulative hazard for overall mortality (ω) using the Akaike Information Criterion. In each sample, increasing GCE risk scores were associated with increased cancer-specific mortality and decreased competing mortality, whereas risk scores from Cox models were associated with both increased cancer-specific mortality and competing mortality. GCE models create...Continue Reading

References

Apr 1, 1992·Statistics in Medicine·E L Korn, F J Dorey
May 15, 1997·The New England Journal of Medicine·F J CouchB L Weber
Jan 27, 2000·JAMA : the Journal of the American Medical Association·J L StanfordA L Potosky
Jan 9, 2001·Journal of Clinical Epidemiology·C N KlabundeJ L Warren
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Athanassios ArgirisEverett E Vokes
May 27, 2004·JAMA : the Journal of the American Medical Association·Jay F PiccirilloEdward L Spitznagel
Dec 7, 2006·Journal of the National Cancer Institute·Joann G Elmore, Suzanne W Fletcher
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Haesook T Kim
Sep 13, 2007·JAMA : the Journal of the American Medical Association·David M Kent, Rodney A Hayward
Nov 23, 2007·The New England Journal of Medicine·Loren K Mell, Ralph R Weichselbaum
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James J Dignam, Maria N Kocherginsky
Nov 19, 2008·BMC Cancer·Ester VilaprinyoMontserrat Rué
Jun 11, 2009·Journal of the National Cancer Institute·John L GoreMark S Litwin
Nov 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Loren K MellRalph R Weichselbaum
Feb 11, 2010·Head & Neck·Frank R DatemaRobert J Baatenburg de Jong
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Aug 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Loren K Mell, Jong-Hyeon Jeong
Aug 26, 2010·Cancer·Loren K MellSteven J Chmura
Apr 28, 2011·Cancer·Timothy J DaskivichMark S Litwin
May 6, 2011·The New England Journal of Medicine·Anna Bill-AxelsonUNKNOWN SPCG-4 Investigators
Aug 17, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brent S RoseLoren K Mell
Jan 28, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James J DignamMasha Kocherginsky
Apr 19, 2012·JAMA : the Journal of the American Medical Association·David M Kent, Nilay D Shah
Mar 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M KwonS Y Kim
Jun 28, 2014·International Journal of Radiation Oncology, Biology, Physics·Ruben CarmonaLoren K Mell
Nov 17, 2014·JAMA : the Journal of the American Medical Association·Jessica L MegaElliott M Antman
Jan 30, 2015·Nature·UNKNOWN Cancer Genome Atlas Network
Feb 12, 2015·The New England Journal of Medicine·Brian D CarterEric J Jacobs
Apr 11, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kaveh ZakeriLoren K Mell

❮ Previous
Next ❯

Citations

Sep 16, 2016·Frontiers in Oncology·Petr Szturz, Jan B Vermorken
Jan 18, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takashi EguchiPrasad S Adusumilli
Jan 16, 2018·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Vivek AgarwalaSudeep Gupta
Nov 20, 2018·JAMA Oncology·Kaveh ZakeriLoren K Mell
Mar 5, 2019·JCO Clinical Cancer Informatics·Paul RiviereJames D Murphy
Jul 31, 2020·JAMA Network Open·Abhishek KumarJames D Murphy
Jan 18, 2019·JCO Clinical Cancer Informatics·Lucas K VitzthumLoren K Mell
Jan 18, 2019·JCO Clinical Cancer Informatics·Kaveh ZakeriLoren K Mell
Oct 6, 2020·Cancer·Kaveh ZakeriUNKNOWN MARCH/MACH-NC Collaborative Group and the Head and Neck Cancer Intergroup
Aug 20, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Loren K MellQuynh-Thu Le
Sep 27, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sarina BainsPrasad S Adusumilli
Mar 27, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Mairéad G McNamaraJuan W Valle
Jan 26, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Hao XingTian Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Lorelei A MucciMark A Rubin
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Kathy HanAnthony W Fyles
© 2022 Meta ULC. All rights reserved