Improved mood states with lamotrigine in patients with epilepsy

Epilepsy & Behavior : E&B
J A CramerR P Kustra

Abstract

Lamotrigine (LTG) was added to other antiepileptic drugs (AEDs) in a study of adjunctive therapy. In addition to seizure control and adverse effects, patients were evaluated for changes in mood states and quality of life. The Profile of Mood States (POMS) and 31-item Quality of Life in Epilepsy (QOLIE-31) instruments were administered at baseline (N=196), after addition of LTG as adjunctive treatment (N=155), and after withdrawal of other drugs to LTG monotherapy (N=51). POMS scores correlated highly with the QOLIE-31 Emotional Well-Being subscale, a known measure of mood. All POMS subscales were significantly improved (all P<0.0001) at the end of the adjunctive therapy phase. POMS scores remained significantly better than baseline among patients completing the conversion to monotherapy (all P<0.003). Minimal clinically important changes were determined for POMS scores. These data indicate that LTG improves mood states to a clinically important degree, even in the presence of other AEDs. The improvement likely was not a synergy but attributable only to LTG because it remained stable after withdrawal of the other AEDs.

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Citations

Apr 26, 2011·Epilepsy & Behavior : E&B·Hiroko KatoKousuke Kanemoto
Oct 27, 2009·Epilepsy & Behavior : E&B·Melanie GalantiZachary N Stowe
Jan 30, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B ClemensK Hollódy
Dec 15, 2006·Epilepsy & Behavior : E&B·Toufic A FakhouryAlain Vuong
Oct 31, 2006·Epilepsy & Behavior : E&B·Alan B EttingerAnne E Hammer
Aug 2, 2005·Epilepsy & Behavior : E&B·Felipe FregniAlvaro Pascual-Leone
Feb 25, 2014·The Tohoku Journal of Experimental Medicine·Yasuhiro MoriSunao Kaneko
Jun 4, 2016·Pharmacological Reviews·Martin J BrodieBernhard J Steinhoff
Aug 12, 2006·Journal of Child Neurology·Raj D Sheth, Barry E Gidal
Jun 18, 2017·Epilepsy & Behavior : E&B·Luba NakhutinaArthur C Grant
Jan 27, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Vladimir V Kalinin
Sep 25, 2017·Frontiers in Psychology·Alessandro QuartiroliGerard J Fogarty

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