Improved muscle healing after contusion injury by the inhibitory effect of suramin on myostatin, a negative regulator of muscle growth

The American Journal of Sports Medicine
Masahiro NozakiJohnny Huard

Abstract

Muscle contusions are the most common muscle injuries in sports medicine. Although these injuries are capable of healing, incomplete functional recovery often occurs. Suramin enhances muscle healing by both stimulating muscle regeneration and preventing fibrosis in contused skeletal muscle. Controlled laboratory study. In vitro: Myoblasts (C2C12 cells) and muscle-derived stem cells (MDSCs) were cultured with suramin, and the potential of suramin to induce their differentiation was evaluated. Furthermore, MDSCs were cocultured with suramin and myostatin (MSTN) to monitor the capability of suramin to neutralize the effect of MSTN. In vivo: Varying concentrations of suramin were injected in the tibialis anterior muscle of mice 2 weeks after muscle contusion injury. Muscle regeneration and scar tissue formation were evaluated by histologic analysis and functional recovery was measured by physiologic testing In vitro: Suramin stimulated the differentiation of myoblasts and MDSCs in a dose-dependent manner. Moreover, suramin neutralized the inhibitory effect of MSTN on MDSC differentiation. In vivo: Suramin treatment significantly promoted muscle regeneration, decreased fibrosis formation, reduced myostatin expression in injured musc...Continue Reading

References

Jan 1, 1978·Advances in Pharmacology and Chemotherapy·F Hawking
Feb 1, 1992·Medicine and Science in Sports and Exercise·T Hurme, H Kalimo
May 1, 1991·The American Journal of Sports Medicine·J B RyanK R Kolakowski
Jul 1, 1991·Medicine and Science in Sports and Exercise·T HurmeM Järvinen
Jan 1, 1991·Pathology, Research and Practice·M D Grounds
Aug 1, 1990·Medicine and Science in Sports and Exercise·W E Garrett
Oct 1, 1989·Medicine and Science in Sports and Exercise·E Schultz
Sep 1, 1987·The American Journal of Sports Medicine·W E GarrettB M Ribbeck
Mar 1, 1985·Muscle & Nerve·E SchultzC R Valliere
Aug 1, 1970·Journal of the Neurological Sciences·M Reznik, W K Engel
Jan 1, 1970·Current Topics in Developmental Biology·D A Fischman
Jan 1, 1983·Medicine and Science in Sports and Exercise·B M Carlson, J A Faulkner
Sep 1, 1984·The Journal of Hand Surgery·W E GarrettJ L Goldner
Nov 1, 1981·The American Journal of Sports Medicine·S T CanaleB L Freeman
Jul 1, 1995·The American Journal of Sports Medicine·C HughesW E Garrett
Sep 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J BittonM R Cooper
Apr 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·D W ThomasJ P Shepherd
Feb 1, 1995·Journal of Pediatric Surgery·K M SullivanN S Adzick
Sep 1, 1994·The American Journal of Sports Medicine·J J CriscoM M Panjabi
Mar 1, 1993·The American Journal of Sports Medicine·D C TaylorW E Garrett
Feb 1, 1996·American Journal of Hematology·J F TisdaleM K Horne
Mar 1, 1996·American Journal of Ophthalmology·R K HemadyM A Eisenberger
Aug 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N A DawsonW D Figg
Dec 1, 1996·Cancer·K KobayashiM J Ratain
Dec 1, 1996·Brain : a Journal of Neurology·V ChaudhryD R Cornblath
Aug 1, 1997·American Journal of Clinical Oncology·A SmithJ Liebmann
Sep 10, 1998·The Journal of Cell Biology·Z QuJ Huard
Jan 30, 1999·The British Journal of Ophthalmology·H MietzM W Lieberman
Mar 4, 2000·The Journal of Bone and Joint Surgery. British Volume·J MenetreyJ Huard
Jul 31, 2001·The American Journal of Sports Medicine·K FukushimaJ Huard
Sep 6, 2002·The American Journal of Pathology·Yong Li, Johnny Huard
Mar 19, 2003·The American Journal of Sports Medicine·J Albert DiazK Donald Shelbourne
May 6, 2003·Journal of Applied Physiology·Yi-Sheng ChanJohnny Huard
Aug 16, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·William FosterJohnny Huard
Dec 22, 2004·The American Journal of Sports Medicine·Yi-Sheng ChanJohnny Huard

❮ Previous
Next ❯

Citations

Jan 30, 1989·Biochimica Et Biophysica Acta·H SychrováA Kotyk
Dec 30, 1981·Biochimica Et Biophysica Acta·A Goffeau, C W Slayman
Feb 22, 2012·Acta Physiologica·B ElliottR Mackenzie
Jan 10, 2012·The Journal of Pharmacology and Experimental Therapeutics·Midhun C KorrapatiRick G Schnellmann
Jul 30, 2011·Skeletal Muscle·Tyesha N Burks, Ronald D Cohn
Jan 1, 2012·ISRN Orthopedics·L BaogeL C Vanden Bossche
Mar 18, 2015·Nature Reviews. Rheumatology·Christopher H Evans, Johnny Huard
Jun 4, 2015·PloS One·Bruno M AndradeJoão Pedro Werneck-de-Castro
Jul 2, 2014·Sports Health·Natalie R DannaJoseph A Bosco
Feb 9, 2017·Tissue Engineering. Part B, Reviews·Justin L MadrigalEduardo A Silva
May 17, 2017·Acta Biochimica Et Biophysica Sinica·Yaying SunHao Ying
May 25, 2016·The American Journal of Sports Medicine·Priscila Martins Andrade DenapoliRene Jorge Abdalla
Oct 31, 2009·The American Journal of Sports Medicine·Timothy E FosterScott A Rodeo
Nov 26, 2010·Muscle & Nerve·Ana Paula Tiemi TanigutiMaria Julia Marques
Sep 14, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Makoto NishimoriJohnny Huard
Oct 19, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xuhui LiuBernard Halloran
May 31, 2012·Muscle & Nerve·Masahiro NozakiJohnny Huard
Sep 17, 2009·Journal of Cellular and Molecular Medicine·Tomoyuki NakasaMitsuo Ochi
Jun 20, 2013·The Journal of Bone and Joint Surgery. American Volume·Satoshi TeradaJohnny Huard
Jan 13, 2018·Journal of Exercise Rehabilitation·Jooyoung Kim, Joohyung Lee
Oct 14, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Svitlana Pasteuning-VuhmanCindy J M Loomans
Oct 9, 2016·Annals of Biomedical Engineering·Kyle S MartinShayn M Peirce
Mar 26, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Aishwariya SharmaAlexander Scott
Mar 16, 2011·Muscle & Nerve·Chad D MarkertRobert W Grange
Jan 1, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Svitlana Pasteuning-VuhmanCindy J M Loomans
Dec 15, 2010·Acta Orthopaedica·Tobias WinklerStephan V Tohtz
Feb 16, 2018·Skeletal Muscle·Anita KneppersRamon Langen
May 10, 2020·Nature Communications·Jung-Min KimJae-Hyuck Shim

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