Improved near infrared-mediated hydrogel formation using diacrylated Pluronic F127-coated upconversion nanoparticles

Materials Science & Engineering. C, Materials for Biological Applications
Kihak GwonGiyoong Tae

Abstract

In situ hydrogel synthesis based on photopolymerization has been recognized as a promising strategy that can be used for tissue augmentation. In this study, we developed an efficient in situ gelation method to prepare bulk hydrogels via near infrared (NIR)-mediated photopolymerization using acrylated polyethylene glycol and diacrylated Pluronic F127-coated upconversion nanoparticles (UCNPs). In our system, upon 980-nm laser irradiation, UCNPs transmit visible light, which triggers the activation of eosin Y to initiate polymerization. We found that the UCNPs coated with diacrylated Pluronic F127 can enhance the photopolymerization efficiency and thus enable the production of bulk hydrogel with requirement of a lower NIR light power compared to that required with the bare UCNPs. This photopolymerization approach will be beneficial to achieve in situ polymerization in vivo for various biomedical applications such as cell/drug delivery and construction of tissue augments.

Citations

Mar 3, 2020·Photochemistry and Photobiology·Ke WangJinfeng Xing
Mar 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali RazaHafiz M N Iqbal
Dec 29, 2020·Carbohydrate Polymers·Khadijeh SoleimaniHadi Samadian
Feb 27, 2021·Biomaterials Science·Feifei WangHongbo Zeng
Jun 20, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Qin LiJinliang Liu

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