PMID: 9556743Apr 29, 1998Paper

Improved nuclear magnetic resonance microscopic visualization of joint cartilage using liposome entrapped contrast agents

Investigative Radiology
W GründerA Werner

Abstract

After intraarticular application of gadolinium (Gd)-DTPA the visualization cartilage surface roughness is limited because of diffusion into the cartilage. To improve the sensitivity of magnetic resonance (MR) arthrography to diagnose cartilage surface abnormalities, the authors have tested liposome-entrapped contrast agents. Using paramagnetic contrast agents (Gd-DTPA and manganese chloride) free and entrapped in liposomes, respectively, high resolution MR imaging investigations were performed at 7.1 tesla on intact pig temporomandibular and rabbit knee joints. After intraarticular injection of the liposome-entrapped contrast agents an excellent contrast between cartilage surface and joint space was achieved. Diffusion of the contrast agent into the cartilage layer was prevented and the visualization of the cartilage surface was improved markedly. Small mechanically and enzymatically induced cartilage lesions could be assessed reliably. Intraarticular injection of liposome-entrapped contrast agents can improve the potential of MR arthrography concerning the detection of early osteoarthritic cartilage changes.

References

Mar 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y KusakaK Gersonde
Jul 1, 1992·Journal of Computer Assisted Tomography·J HodlerD Resnick
Nov 1, 1991·Investigative Radiology·T FritzC Tilcock
Apr 1, 1989·Radiology·C TilcockP MacDougall
Apr 1, 1989·Radiology·E C UngerC Tilcock
Jun 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R L MaginH M Swartz
Mar 1, 1994·Journal of Computer Assisted Tomography·J KramerA Engel
Oct 1, 1994·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·S HögerleE Löhr
Feb 1, 1994·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·G AdamR W Günther
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A BashirD Burstein

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Citations

Jan 26, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Erik M ShapiroRavinder Reddy
Aug 19, 2011·Skeletal Radiology·Carl S Winalski, Prabhakar Rajiah
Apr 25, 2000·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·M L Matteucci, D E Thrall
Sep 24, 2005·AJR. American Journal of Roentgenology·Michael P RechtLawrence M White
May 19, 2010·International Journal of Molecular Sciences·Nazila Kamaly, Andrew D Miller
Apr 5, 2014·Contrast Media & Molecular Imaging·Mohammed Salman ShazeebAlexei Bogdanov
Feb 7, 2006·International Journal of Pharmaceutics·Uyen M Le, Zhengrong Cui
Apr 7, 2004·Magnetic Resonance Imaging Clinics of North America·Garry E GoldChristopher F Beaulieu
Apr 6, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ananta Laxmi AyyagariRavi V Bellamkonda
Oct 21, 2000·Investigative Radiology·D BursteinM L Gray
Dec 10, 1999·Investigative Radiology·V M Runge
Oct 6, 1999·Investigative Radiology·M WagnerW Gründer

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