Improved Open-Loop Glucose Control With Basal Insulin Reduction 90 Minutes Before Aerobic Exercise in Patients With Type 1 Diabetes on Continuous Subcutaneous Insulin Infusion

Diabetes Care
Dessi ZaharievaMichael C Riddell

Abstract

To reduce exercise-associated hypoglycemia, individuals with type 1 diabetes on continuous subcutaneous insulin infusion typically perform basal rate reductions (BRRs) and/or carbohydrate feeding, although the timing and amount of BRRs necessary to prevent hypoglycemia are unclear. The goal of this study was to determine if BRRs set 90 min pre-exercise better attenuate hypoglycemia versus pump suspension (PS) at exercise onset. Seventeen individuals completed three 60-min treadmill exercise (∼50% of VO2peak) visits in a randomized crossover design. The insulin strategies included 1) PS at exercise onset, 2) 80% BRR set 90 min pre-exercise, and 3) 50% BRR set 90 min pre-exercise. Blood glucose level at exercise onset was higher with 50% BRR (191 ± 49 mg/dL) vs. 80% BRR (164 ± 41 mg/dL; P < 0.001) and PS (164 ± 45 mg/dL; P < 0.001). By exercise end, 80% BRR showed the smallest drop (-31 ± 58 mg/dL) vs. 50% BRR (-47 ± 50 mg/dL; P = 0.04) and PS (-67 ± 41 mg/dL; P < 0.001). With PS, 7 out of 17 participants developed hypoglycemia versus 1 out of 17 in both BRR conditions (P < 0.05). Following a standardized meal postexercise, glucose rose with PS and 50% BRR (both P < 0.05), but failed to rise with 80% BRR (P = 0.16). Based on inte...Continue Reading

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Citations

Jan 9, 2020·Current Pharmaceutical Design·Othmar MoserPeter Hofmann
Oct 5, 2019·Journal of Diabetes Science and Technology·Michael Müller-KorbschPeter Fasching
Feb 23, 2020·Expert Opinion on Drug Delivery·Klemen Dovc, Tadej Battelino
Jun 11, 2020·Sensors·Nichole S Tyler, Peter G Jacobs
Jun 14, 2020·Diabetologia·Michael C RiddellRichard M Bracken
Dec 15, 2019·Nutrients·Sam ScottChristoph Stettler
Feb 19, 2020·Diabetes Technology & Therapeutics·Dessi P ZaharievaMichael C Riddell
Oct 28, 2020·Current Obesity Reports·Dessi P ZaharievaDavid M Maahs
Dec 22, 2020·Journal of Diabetes Science and Technology·Sarah M McGaughMichael C Riddell

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