Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects

Journal of Biomedical Materials Research. Part a
Xiang LuXuebin Zheng

Abstract

Osteoimmunology has revealed the importance of a favorable immune response for successful biomaterial-mediated osteogenesis. Boron-incorporated calcium silicate (Ca11 Si4 B2 O22 , B-CS) coating has been reported as a potential candidate for improving osteogenesis in orthopedic applications in vitro. However, relatively little is known about its effects on the immune response and subsequent osteogenesis. In this work, the immunomodulatory properties of the B-CS coating and its specific mechanism of action were explored. We found that the B-CS coating decreased M1 polarization and converted macrophages to the M2 phenotype via restraining the TLR signaling pathway, thus inducing a significant reduction in pro-inflammatory cytokines and an increase in anti-inflammatory cytokines. Moreover, the B-CS coating inhibited osteoclastogenesis and osteoclastic activities by downregulating osteoclastogenic genes and inhibiting the RANKL/RANK system. BMP2 and VEGF were also significantly upregulated by macrophages and bone mesenchymal stem cells (BMSCs), leading to activation of the BMP2 signaling pathway and subsequent upregulation of osteogenesis-associated genes, finally promoting osteogenic differentiation. These findings show that the B-CS c...Continue Reading

References

Mar 8, 2002·Biological Trace Element Research·M Dzondo-GadetB Dousset
Sep 18, 2002·The Journal of Clinical Investigation·Hairong PengJohnny Huard
May 16, 2003·Nature·William J BoyleDavid L Lacey
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Sep 30, 2004·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
Dec 17, 2005·Trends in Molecular Medicine·Teiji WadaJosef M Penninger
Mar 23, 2006·Annual Review of Immunology·Matthew C WalshYongwon Choi
Apr 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mattabhorn PhimphilaiRenny T Franceschi
Apr 26, 2007·Nature Reviews. Immunology·Luke A J O'Neill, Andrew G Bowie
May 16, 2007·Journal of Biomedical Materials Research. Part a·Jacqueline A JonesJames M Anderson
Aug 30, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Jun CaoLaifu Zhong
Feb 5, 2009·Critical Reviews in Eukaryotic Gene Expression·Carrie S SoltanoffYi-Ping Li
Aug 12, 2009·Clinical Oral Implants Research·Ann Wennerberg, Tomas Albrektsson
Aug 12, 2009·Biological Trace Element Research·Romulus Ion ScoreiDana Iordachescu
Oct 9, 2009·Trends in Molecular Medicine·Fabien WauquierYohann Wittrant
Aug 6, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Sema S HakkiErdogan E Hakki
Dec 7, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Mohammad Reza NaghiiMaryam-Saddat Daneshpour
Jan 29, 2011·Biological Trace Element Research·Romulus Ion Scorei, Petre Rotaru
Jun 1, 2011·Biological Trace Element Research·Xiaozhou YingChuan Zhu Lu
Nov 15, 2011·Critical Reviews in Eukaryotic Gene Expression·Jonathan W LoweryVicki Rosen
Apr 19, 2013·Journal of Biomedical Materials Research. Part a·Mohammed A AlfarsiSaso Ivanovski
Aug 29, 2013·Biological Trace Element Research·Iulia Daria Scorei, Romulus Ion Scorei
Sep 17, 2013·Journal of Periodontal Research·M SağlamS Kelebek
Jul 27, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Forrest H Nielsen
Dec 18, 2015·Acta Biomaterialia·Kelly M HotchkissRene Olivares-Navarrete
Jan 7, 2016·Biomaterials·Richard J Miron, Dieter D Bosshardt
Feb 20, 2016·Nature Reviews. Endocrinology·Valerie S SalazarVicki Rosen
Mar 8, 2016·Bone·Florence LoiStuart B Goodman
Jan 1, 2014·MRS Bulletin·Jamal S LewisBenjamin G Keselowsky
May 4, 2016·Trends in Biotechnology·Ajaykumar VishwakarmaAli Khademhosseini
Sep 25, 2016·Journal of Materials Science. Materials in Medicine·Xiang LuXuebin Zheng

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Citations

Feb 2, 2021·Frontiers in Cell and Developmental Biology·Elia Bosch-RuéRoman A Perez
Aug 22, 2021·Acta Biomaterialia·Kai ZhengAldo R Boccaccini

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