Improved osteoinduction of cortical bone allografts: a study of the effects of laser perforation and partial demineralization

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
K U LewandrowskiH J Mankin

Abstract

Massive cortical bone allografts have been found to incorporate slowly into host bone and thus are subject to complications such as nonunion, fatigue fracture, and infection. To better understand and improve the process of osteoinduction in these types of bone grafts, a new experimental model was developed with use of diaphyseal cortical bone grafts from rat tibiae that were prepared by partial demineralization and drilling of 0.33 mm diameter holes with a pulsed, 2.94 microns wavelength, erbium:yttrium-aluminum-garnet laser. Six types of grafts were analyzed: untreated (Type I), demineralized 25 microns deep (Type II), demineralized 150 microns deep (Type III), laser perforated (Type V), laser perforated and then demineralized 25 microns deep (Type V), and laser perforated and then demineralized 150 microns deep (Type VI). The graft was orthotopically transplanted in the tibia of an adult Sprague-Dawley rat and followed for as long as 4 months. Histologic evaluation at 1 and 4 months postoperatively with use of hematoxylin and eosin staining confirmed that there was new bone growth in Types II, III, V, and VI grafts. The amount of growth was estimated by comparing bone mineral density before implantation with values obtained a...Continue Reading

References

Sep 1, 1992·The Journal of Craniofacial Surgery·K E SalyerJ Bardach
Jun 1, 1992·The Journal of Arthroplasty·M H HuoE A Salvati
Sep 1, 1991·The Journal of Bone and Joint Surgery. British Volume·M Z GuoL B Lin
Jan 1, 1990·The Journal of Craniofacial Surgery·J O Hollinger, J C Kleinschmidt
Jul 1, 1991·The Journal of Bone and Joint Surgery. British Volume·R A PowerH J Mankin
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S BernickM E Nimni
Jan 1, 1989·Lasers in Surgery and Medicine·J T WalshT F Deutsch
Jan 1, 1988·Lasers in Surgery and Medicine·R C NussC A Puliafito
Jul 1, 1986·Journal of Biomedical Materials Research·E Gendler
Nov 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M Hosny, M Sharawy
Dec 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M Hosny, M Sharawy
Jul 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·A H Reddi, C B Huggins
Mar 1, 1982·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R NarangD M Laskin
Jun 1, 1984·The Journal of Cell Biology·T K Sampath, A H Reddi
Oct 1, 1982·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·L B KabanJ Glowacki
Aug 1, 1993·Annals of Medicine·H T Aro, A J Aho
Mar 1, 1996·Clinical Orthopaedics and Related Research·H J MankinW W Tomford
Jan 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R J O'DonnellK T Schomacker
Jan 17, 2002·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·K U LewandrowskiW W Tomford

❮ Previous
Next ❯

Citations

Jun 19, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Takeshi OgawaNaoyuki Ochiai
Aug 15, 2000·Tissue Engineering·S BondreD J Trantolo
Apr 14, 2007·Tissue Engineering·James D Kretlow, Antonios G Mikos
Nov 17, 2012·International Journal of Medical Sciences·Renato ValiatiRogério Miranda Pagnoncelli
Sep 3, 1999·The Orthopedic Clinics of North America·S Stevenson
Jul 2, 2008·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·David TemplinDennis S Weiner
Jul 2, 2015·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Mahdi KadkhodazadehReza Amid
Apr 3, 2010·Clinical Orthopaedics and Related Research·Constantinos KetonisJavad Parvizi
Dec 28, 2018·Plastic and Reconstructive Surgery·Richard P ClarkGranger B Wong
Oct 3, 2006·Journal of Biomedical Materials Research. Part a·J B ChenW R Walsh
May 29, 2008·Journal of Orthopaedic Surgery and Research·Brandon G SantoniDonna L Wheeler
Feb 23, 2002·Clinical Orthopaedics and Related Research·Christian DelloyeDaniel Schmitt
Jun 3, 2005·Clinical Orthopaedics and Related Research·Donna L Wheeler, William F Enneking
Jan 26, 1999·Clinical Orthopaedics and Related Research·S Stevenson
Jan 17, 2002·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·K U LewandrowskiW W Tomford

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
R J O'DonnellK T Schomacker
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
S BernickM E Nimni
Photomedicine and Laser Surgery
Aldo Brugnera Junior
© 2021 Meta ULC. All rights reserved