Improved outcome after primary vitrectomy in diabetic patients treated with statins

European Journal of Ophthalmology
Raimo TuuminenSirpa Loukovaara

Abstract

To evaluate the effect of preoperative statin treatment on the outcome of primary vitrectomy in type 1 and 2 diabetic patients. In this open, observational institutional study, a total of 192 eyes of 171 type 1 and 2 adult diabetic patients admitted for primary vitrectomy for management of sight-threatening forms of diabetic retinopathy were divided according to the use of lipid-lowering therapy: those with statin treatment (79 eyes of 73 patients) and those taking no statin medication (113 eyes of 98 patients). One-month best-corrected visual acuity (BCVA) gain and cumulative 12-month revitrectomy frequency were analyzed. In multivariate linear regression, diabetic patients with statin treatment had a better 1-month BCVA improvement than did those without statin treatment (absolute difference 0.26, 95% confidence interval [CI] 0.02-0.50, p = 0.028). Subgroup analysis revealed that diabetic patients on statin had better postoperative BCVA improvement when preoperative status included partial or panretinal laser photocoagulation (p = 0.042 and p = 0.049) and anti-vascular endothelial growth factor therapy (p = 0.011). Moreover, diabetic patients with preoperative macular edema (p = 0.009), vitreous hemorrhage (p<0.001), proli...Continue Reading

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Citations

Dec 11, 2017·Journal of Cataract and Refractive Surgery·Petteri YlinenRaimo Tuuminen
Jan 18, 2018·Acta Ophthalmologica·Sirpa LoukovaaraJari Haukka
Feb 1, 2017·World Journal of Diabetes·Estelle IoannidouKonstantinos Tziomalos
Mar 31, 2016·Clinical & Experimental Ophthalmology·Tarun SharmaDennis Lam
Mar 5, 2021·International Journal of Nanomedicine·Yuxin Liu, Na Wu
Oct 12, 2018·American Journal of Ophthalmology·Reeta DanniRaimo Tuuminen

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