Improved outcome in South African children of mixed ethnicity treated for all

Pediatric Hematology and Oncology
A DippenaarP B Hesseling

Abstract

A historical cohort study with an analytical component was conducted to determine whether risk-appropriate chemotherapy can improve survival in children of mixed ethnicity with ALL. Eighty-one coloured children treated for ALL in South Africa were divided into 2 groups: group A (n = 39), treated prior to 1992, and group B (n = 42), treated after 1992. A comparison was made of survival, treatment complications, and supportive measures. The two groups were comparable. The mean nadirs of the white cell count (p < .01), platelet count (p = .01), and hemoglobin value (p < .01) were significantly lower in group B. The survival rate of 37% in group A improved to 66% in group B (p = .025). The results show that a risk-adapted regimen increased survival in children of mixed ethnicity in the Western Cape, despite increased hematological toxicity and episodes of febrile neutropenia.

References

Jan 1, 1986·The American Journal of Pediatric Hematology/oncology·L G MacdougallR Bernstein
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M SmithR Ungerleider
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B H PollockS B Murphy
Apr 16, 2002·Current Problems in Pediatric and Adolescent Health Care·Ka Wah Chan
Dec 20, 2002·Current Opinion in Oncology·Yaddanapudi Ravindranath

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Citations

Mar 31, 2012·Blood·Satish GopalRonald T Mitsuyasu

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