Improved outcome of biliary atresia with postoperative high-dose steroid

Gastroenterology Research and Practice
Rui DongXianmin Xiao

Abstract

Objective. The dosage, duration, and the benefits of high-dose steroid treatment and outcome in biliary atresia (BA) remain controversial. In this study, we evaluated the impact of high-dose steroid therapy on the outcome of BA after the Kasai procedure. Methods. Intravenous prednisolone administration was started 1 week after surgery, followed by 8 to 12 weeks of oral prednisolone. Total bilirubin (TB) levels (3, 6, and 12 months after surgery), early onset of cholangitis, and two-year native liver survival were evaluated. Results. 53.4%, 56.9%, and 58.1% of the patients in the high-dose steroid group were jaundice-free 3, 6, and 12 months after surgery, respectively; these values were significantly higher than the 38.7%, 39.4%, and 43.3% of the low-dose steroid group. One year after surgery, the incidence of cholangitis in the high-dose group (32.0%) was lower than that in the low-dose group (48.0%). Infants with native liver in the high-dose group had a better two-year survival compared to those in the low-dose steroid group (53.7% versus 42.6%). Conclusions. The high-dose steroid protocol can reduce the incidence of cholangitis, increase the jaundice-free rate, and improve two-year survival with native liver after the Kasai...Continue Reading

References

Apr 1, 1979·Biochemical Pharmacology·P B Miner, J M Gaito
Dec 1, 1985·Journal of Pediatric Surgery·F M Karrer, J R Lilly
May 1, 1993·World Journal of Surgery·T MiyanoH Shimomura
Mar 1, 1997·Journal of Pediatric Surgery·M DavenportE R Howard
Jul 1, 1997·Journal of Pediatric Surgery·T Muraji, Y Higashimoto
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C ChardotB Auvert
Jan 11, 2001·Journal of Pediatric Surgery·P W DillonK Georgeson
Jul 16, 2003·Journal of Pediatric Surgery·Masaki NioUNKNOWN Japanese Biliary Atresia Registry
Dec 24, 2004·Journal of Pediatric Surgery·Toshihiro MurajiUNKNOWN Japanese Biliary Atresia Society
Mar 17, 2005·Seminars in Pediatric Surgery·Mark Davenport
Jan 18, 2006·Journal of Pediatric Surgery·Mauricio A EscobarJay L Grosfeld
Sep 29, 2006·Indian Journal of Pediatrics·Mark Davenport
May 16, 2007·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·S ShimaderaS Ono
Aug 21, 2007·Journal of Pediatric Surgery·Mark D StringerPatricia McClean
Sep 20, 2007·Archives of Disease in Childhood·Deirdre A Kelly, Mark Davenport
Oct 16, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark DavenportNedim Hadzic
Jan 8, 2008·The American Journal of Gastroenterology·Claus PetersenBenno M Ure
Apr 29, 2010·Current Gastroenterology Reports·Jorge L SantosJorge A Bezerra
Jun 4, 2011·Pharmacogenomics·Erik J M ToonenWynand Alkema
Jan 11, 2013·ISRN Surgery·Barbara E Wildhaber

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Citations

Sep 25, 2017·Pediatric Surgery International·Mark Davenport
May 16, 2018·The Cochrane Database of Systematic Reviews·Athanasios TyraskisMark Davenport
Jul 25, 2019·Journal of Pediatric Gastroenterology and Nutrition·Martina FannaChristophe Chardot
Jun 3, 2020·Pediatric Gastroenterology, Hepatology & Nutrition·Noha Adel YassinHanaa El-Karaksy
Jul 12, 2017·Gastroenterology Research and Practice·Rui DongShan Zheng

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