Improved outcome of EAN, an animal model of GBS, through amelioration of peripheral and central inflammation by minocycline.

Journal of Cellular and Molecular Medicine
Zhi-Yuan ZhangHermann J Schluesener

Abstract

Experimental autoimmune neuritis (EAN) is a widely used animal model of the human acute inflammatory demyelinating polyradiculoneuropathy, which is the most common subtype of Guillain-Barré Syndrome. EAN is pathologically characterized by breakdown of the blood-nerve barrier, infiltration of reactive immune cells, local inflammation, demyelination in the peripheral nervous system and mechanical allodynia. Minocycline is known to have neuroprotective and anti-inflammatory effects. Furthermore, relieve of neuropathic pain following minocycline administration was observed in a variety of animal models. Here, we investigated the effects of minocycline on rat EAN. Suppressive treatment with minocycline (50 mg/kg body weight daily immediately after immunization) significantly attenuated the severity and duration of EAN. Macrophage and T-cell infiltration and demyelination in sciatic nerves of EAN rats treated with minocycline were significantly reduced compared to phosphate-buffered saline (PBS)-treated EAN rats. mRNA expressions of matrix metallopeptidase-9, inducible nitric oxide synthase and pro-inflammatory cytokines interleukin-1 beta and tumour necrosis factor-alpha in EAN sciatic nerves were greatly decreased by administration...Continue Reading

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Citations

Nov 26, 2010·Journal of Neurology·Ming-Ou Lu, Jie Zhu
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Methods Mentioned

BETA
light microscopy
fluorescent-activated
PCR
FACS
electrophoresis

Software Mentioned

BioDocAnalyze
MetaMorph Offline
Graph Pad Prism

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